{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:27:07Z","timestamp":1747186027825,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serum high\u2010molecular\u2010weight adiponectin (HMWA) has a positive correlation with insulin secretion in the Japanese population. To validate this correlation, we investigated the correlation between serum HMWA and proinsulin, a marker of \u03b2\u2010cell dysfunction, in this population. A total of 488 participants (53.9% women) aged 35\u201379\u00a0years not taking oral hypoglycemic agents and\/or insulin were enrolled. HMWA was significantly and inversely correlated with proinsulin adjusted for age and sex (partial regression coefficient \u03b2\u00a0=\u00a0\u22120.37; 95% confidence interval \u22120.46 to \u22120.28). When the participants were divided into two groups by median values of body mass index (23.2\u00a0kg\/m<jats:sup>2<\/jats:sup>), serum insulin (4.3\u00a0\u00b5U\/mL) or homeostasis model assessment of insulin resistance (1.0), similar inverse correlations were observed adjusted for age and sex in both groups. Our results showed that the HMWA level was inversely correlated with the proinsulin level in a general Japanese population.<\/jats:p>","DOI":"10.1111\/jdi.13323","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T22:03:43Z","timestamp":1591999423000},"page":"63-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Inverse correlation between serum high\u2010molecular\u2010weight adiponectin and proinsulin level in a Japanese population: The Dynamics of Lifestyle and Neighborhood Community on Health Study"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8192-0006","authenticated-orcid":false,"given":"Akinobu","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo 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