{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:33:37Z","timestamp":1754109217733,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Despite increasing interest in growth differentiation factor\u00a011 (GDF11) based on its involvement in age\u2010related disorders, clinical implications \u2013 especially for metabolic diseases \u2013 remain unclear. Therefore, we assessed the association between serum GDF11 levels and metabolic disturbance in the Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 381 individuals from the Shanghai Nicheng Cohort Study were included. In addition to anthropometry, laboratory and ultrasonography measurements, serum concentrations of GDF11 were measured by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Circulating GDF11 concentrations were unchanged with age (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u20130.064, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.210), but showed an inverse relationship to body mass index, waist circumference and fat\u2010free mass index (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Correlation analysis showed decreased GDF11 concentrations accompanied by elevated diastolic blood pressure, fasting and 2\u2010h plasma glucose, triglycerides, and low\u2010density lipoprotein cholesterol after adjusting for sex, age and body mass index, whereas variations in aspartate aminotransferase and free thyroxine were consistent with GDF11 (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Furthermore, people, especially men, with abnormal glycometabolism, body mass index and\/or fat accumulation in the liver had lower serum levels of GDF11 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05); an increase in metabolic syndrome morbidity along with the circulatory decline of GDF11 was found when stratified by GDF11\u2010level quartiles (<jats:italic>P<\/jats:italic>\u2010trend &lt;0.001). Logistic regression showed that serum GDF11 levels were independently correlated with the presence of metabolic syndrome (odds ratio 0.665, 95% confidence interval 0.510\u20130.867, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We confirmed GDF11 as an endocrine factor playing a significant role in multiple metabolic processes and an indicator of metabolic syndrome in the Chinese population, particularly in males.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13337","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T21:00:30Z","timestamp":1593291630000},"page":"234-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Serum growth differentiation factor\u00a011 is closely related to metabolic syndrome in a Chinese cohort"],"prefix":"10.1111","volume":"12","author":[{"given":"Bo","family":"Xu","sequence":"first","affiliation":[{"name":"Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes Mellitus Shanghai Clinical Center for Diabetes Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7806-5697","authenticated-orcid":false,"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Kidney Diseases Jinling Hospital Nanjing University School of Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes Mellitus Shanghai Clinical Center for Diabetes Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital Shanghai 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Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yicen","family":"Zong","sequence":"additional","affiliation":[{"name":"Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes Mellitus Shanghai Clinical Center for Diabetes Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4314-2386","authenticated-orcid":false,"given":"Cheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes Mellitus Shanghai Clinical Center for Diabetes Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital Shanghai China"},{"name":"Department of Endocrinology and Metabolism Fengxian Central Hospital Affiliated to the Southern Medical University Shanghai 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