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The molecular mechanism involves the sensing of glucose flux by the hexosamine biosynthesis pathway, which leads to the adjustment of cellular metabolism to protect against changes in the environment of each organ through O\u2010GlcNAcylation. More recently, not only glucose, but also fluxes of amino acids and fatty acids have been reported to induce O\u2010GlcNAcylation, affecting multiple cellular processes. In this review, we discuss how O\u2010GlcNAcylation maintains homeostasis in organs that are affected by diabetes mellitus: skeletal muscle, adipose tissue, liver and pancreatic \u03b2\u2010cells. Furthermore, we discuss the importance of O\u2010GlcNAcylation in the pathogenesis of diabetic complications. By elucidating the molecular mechanisms whereby cellular homeostasis is maintained, despite changes in metabolic flux, these studies might provide new targets for the treatment and prevention of diabetes and its complications.<\/jats:p>","DOI":"10.1111\/jdi.13359","type":"journal-article","created":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T14:18:21Z","timestamp":1594563501000},"page":"130-136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Role of O\u2010linked N\u2010acetylglucosamine in the homeostasis of metabolic organs, and its potential links with diabetes and its complications"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2420-3817","authenticated-orcid":false,"given":"Katsutaro","family":"Morino","sequence":"first","affiliation":[{"name":"Division of Diabetology, Endocrinology, and Nephrology Department of Medicine Shiga University of Medical Science Otsu 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