{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:49:20Z","timestamp":1793278160768,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Alcohol consumption has been reported to cause hypoglycemia. However, the mechanism involved has not been unequivocally established. This study comprised healthy volunteers. We carried out a prospective trial to compare the effects of glucose and alcohol consumption, alone or in combination, on glucose and lipid metabolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A 75\u2010g oral glucose tolerance test (OGTT), a combined 75\u2010g glucose plus 20\u2010g alcohol tolerance test (OGATT) and a 20\u2010g alcohol tolerance test (OATT) were carried out in the participants. Plasma glucose, insulin, triglyceride and ethanol concentrations during each test were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We studied 10 participants. Their plasma glucose concentrations 15 and 30\u00a0min after the intake of 75\u00a0g of glucose were significantly higher during the OGATT than the OGTT. Hypoglycemia occurred in five participants after the OGATT, which was significantly more frequently than after the OGTT (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.046). Hypoglycemia did not occur after the OATT, and the ethanol concentration was significantly lower after the OGATT than the OATT. The changes in triglyceride concentration from 30\u00a0min after the consumption of 75\u00a0g of glucose were significantly greater during the OGATT than the OGTT. The plasma insulin concentrations peaked after 60\u00a0min during both the OGTT and OGATT, and were significantly higher during the OGATT (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.047). There were no differences between the two interventions in the Matsuda or disposition indexes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hypoglycemia occurred more frequently after the simultaneous consumption of alcohol plus glucose than after the consumption of glucose alone, suggesting that alcohol in the combination of glucose induces reactive hypoglycemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13375","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T20:30:02Z","timestamp":1596054602000},"page":"651-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Combination of alcohol and glucose consumption as a risk to induce reactive hypoglycemia"],"prefix":"10.1111","volume":"12","author":[{"given":"Chiho","family":"Oba\u2010Yamamoto","sequence":"first","affiliation":[{"name":"Sapporo Diabetes and Thyroid Clinic Sapporo 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