{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:49:01Z","timestamp":1788828541528,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Introduction<\/jats:title>\n                    <jats:p>Glucosuria is a representative symptom in diabetes patients with poor glycemic control and in those treated with sodium\u2013glucose cotransporter\u00a02 inhibitors. Renal threshold levels of glucose excretion are known to vary among individuals, but factors contributing to glucosuria are not well characterized. The present study aimed to clarify clinical and genetic determinants of glucosuria in individuals with diabetes mellitus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      The 24\u2010h urinary glucose excretion was measured in 135 hospitalized patients on admission, with continuous measurement for five consecutive days in 75 patients. Genetic and clinical factors contributing to glucosuria were studied. As a genetic factor,\n                      <jats:italic>SLC5A2<\/jats:italic>\n                      polymorphism was genotyped. A total of 476 participants (266 participants with type\u00a02 diabetes and 210 healthy controls) were additionally genotyped for the association study of\n                      <jats:italic>SLC5A2<\/jats:italic>\n                      with type\u00a02 diabetes. A meta\u2010analysis was carried out with the present study and previous association studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multiple regression analysis showed that the independent variables of average blood glucose (\u03b2\u00a0=\u00a00.41,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a01.4\u00a0\u00d7\u00a010\n                      <jats:sup>\u22127<\/jats:sup>\n                      ), estimated glomerular filtration rate (\u03b2\u00a0=\u00a00.28,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a06.0\u00a0\u00d7\u00a010\n                      <jats:sup>\u22125<\/jats:sup>\n                      ), sex (\u03b2\u00a0=\u00a00.28,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a05.7\u00a0\u00d7\u00a010\n                      <jats:sup>\u22125<\/jats:sup>\n                      ) and\n                      <jats:italic>SLC5A2<\/jats:italic>\n                      rs9934336 polymorphism (\u03b2\u00a0=\u00a00.17,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.02) were significantly correlated with urinary glucose excretion. The frequency of the A allele of rs9934336 tended to be lower in participants with type\u00a02 diabetes than in controls (odds ratio 0.78, 95% confidence interval 0.53\u20131.13, not significant), and meta\u2010analysis showed a significant association between the A allele and type\u00a02 diabetes (summary odds ratio for minor allele [A] 0.86, 95% confidence interval 0.78\u20130.94,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Blood glucose, estimated glomerular filtration rate, sex and\n                      <jats:italic>SLC5A2<\/jats:italic>\n                      polymorphism were independent determinants of glucosuria in diabetes mellitus.\n                    <\/jats:p>\n                  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