{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T23:32:52Z","timestamp":1772235172305,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>As a low\u2010carbohydrate diet and the use of sodium\u2013glucose transporter\u20102 inhibitors are both known to increase D\u2010beta\u2010hydroxybutyrate levels, the effect of these levels on glucose metabolism has attracted attention. We investigated the acute effects of ketone monoester (KM) ingestion on blood glucose levels during the 75\u2010g oral glucose tolerance test (OGTT) in participants with impaired glucose tolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Nine Japanese adults aged 48\u201362\u00a0years (4 men, 5 women) with impaired glucose tolerance participated in this study. After participants fasted overnight, we carried out OGTT for 180\u00a0min with and without KM ingestion on two separate days in a randomized cross\u2010over design. We compared the area under the curve (AUC) of D\u2010beta\u2010hydroxybutyrate, glucose, insulin, C\u2010peptide, glucagon and free fatty acids during OGTT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The AUC of D\u2010beta\u2010hydroxybutyrate during OGTT was significantly higher with KM than without KM (KM 5995.3\u00a0\u00b1\u00a01257.1\u00a0mmol\/L\u00b7h; without KM 116.1\u00a0\u00b1\u00a033.9\u00a0mmol\/L\u00b7h, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), and the AUC of glucose with KM was significantly lower than that without KM (KM 406.6\u00a0\u00b1\u00a070.6\u00a0mg\/dL\u00b7h; without KM 483.2\u00a0\u00b1\u00a074.3\u00a0mg\/dL\u00b7h, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001). This improved glucose excursion was associated with enhanced AUC of insulin during the first half (0\u201390\u00a0min) of OGTT, even though the AUC of C\u2010peptide during this period was unchanged. In contrast, the AUC of insulin, C\u2010peptide, glucagon and free fatty acids during 180\u00a0min of OGTT were similar in both conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The ingestion of KM decreased the AUC of glucose during 75\u2010g OGTT in Japanese individuals with impaired glucose tolerance, and the mechanism might involve elevated levels of circulating early phase insulin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13423","type":"journal-article","created":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T14:45:37Z","timestamp":1601736337000},"page":"756-762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Ingestion of an exogenous ketone monoester improves the glycemic response during oral glucose tolerance test in individuals with impaired glucose tolerance: A cross\u2010over randomized trial"],"prefix":"10.1111","volume":"12","author":[{"given":"Takashi","family":"Nakagata","sequence":"first","affiliation":[{"name":"Sportology Center Juntendo University Graduate School of Medicine Tokyo Japan"},{"name":"Department of Metabolism &amp; Endocrinology Juntendo University Graduate School of Medicine Tokyo Japan"},{"name":"Department of Physical Activity Research National Institute of Health and Nutrition NIBIOHN Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1685-7821","authenticated-orcid":false,"given":"Yoshifumi","family":"Tamura","sequence":"additional","affiliation":[{"name":"Sportology Center Juntendo University Graduate School of Medicine Tokyo Japan"},{"name":"Department of Metabolism &amp; Endocrinology Juntendo University Graduate School of Medicine Tokyo 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