{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:26:20Z","timestamp":1791239180458,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400785"],"award-info":[{"award-number":["81400785"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870596"],"award-info":[{"award-number":["81870596"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease, especially with liver fibrosis, is associated with cardiovascular diseases. The Non\u2010Alcoholic Fatty Liver Disease Fibrosis Score (NFS), a non\u2010invasive marker of advanced fibrosis, was found to be associated with cardiovascular diseases in different populations. The aim of the present study was to determine whether the NFS is associated with subclinical myocardial remodeling in type\u00a02 diabetes patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A cross\u2010sectional study was carried out in type\u00a02 diabetes patients. The NFS derived from available parameters was calculated, and the participants were divided according to the quartiles of the NFS and grades of the NFS (low, intermediate and high). Fibrosis\u20104 and Aspartate Aminotransferase to Platelet Ratio Index, another two liver fibrosis scores, were also calculated. Subclinical myocardial remodeling was examined by echocardiography, and its associations with NFS, Fibrosis\u20104 and Aspartate Aminotransferase to Platelet Ratio Index were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1,878 type\u00a02 diabetes patients were enrolled in the present study. The NFS was independently associated with sex, age, body mass index, low\u2010density lipoprotein cholesterol and glycated hemoglobin in type\u00a02 diabetes patients. Parameters of subclinical myocardial remodeling including left atrial dimension, interventricular septum thickness, left ventricular end\u2010diastolic diameter, left ventricular end\u2010systolic diameter, left ventricular posterior wall thickness (LVPWT) and left ventricular mass index were all gradually increased with the increment of the NFS. Linear regression analysis further showed that the NFS was positively associated with left atrial dimension, interventricular septum thickness, left ventricular end\u2010diastolic diameter, left ventricular end\u2010systolic diameter, LVPWT and left ventricular mass index after adjustment for the confounding factors. Similarly, Fibrosis\u20104 was associated with left atrial dimension, interventricular septum thickness, LVPWT and left ventricular mass index. In contrast, the Aspartate Aminotransferase to Platelet Ratio Index was only associated with LVPWT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Non\u2010invasive liver fibrosis scores, especially the NFS, are independently associated with subclinical myocardial remodeling in type\u00a02 diabetes patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13430","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T18:29:32Z","timestamp":1602181772000},"page":"1035-1041","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association of the Non\u2010Alcoholic Fatty Liver Disease Fibrosis Score with subclinical myocardial remodeling in patients with type\u00a02 diabetes: A cross\u2010sectional study in China"],"prefix":"10.1111","volume":"12","author":[{"given":"Nengguang","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai General Hospital Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai General Hospital Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai General Hospital Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai General Hospital Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aifang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology 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