{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:06:10Z","timestamp":1780351570885,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>To define the target value for the percentage coefficient of variation for glucose (%CV) as a measure of glycemic variability (GV) in Chinese diabetes patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This retrospective study included 3,007 diabetes patients who underwent continuous glucose monitoring for 3\u00a0days. Type\u00a02 diabetes was divided into groups according to the received treatment: group\u00a01, non\u2010insulinotropic agent (<jats:italic>n<\/jats:italic>\u00a0=\u00a0138); group\u00a02, insulinotropic agent (<jats:italic>n<\/jats:italic>\u00a0=\u00a0761); group\u00a03, basal insulin therapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a0100); group\u00a04, premixed insulin (<jats:italic>n<\/jats:italic>\u00a0=\u00a0784); and group\u00a05, intensive insulin therapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a0612). Type\u00a01 diabetes patients were included as group\u00a06 (<jats:italic>n<\/jats:italic>\u00a0=\u00a0612). %CV and percentage of time per day within, below (3.9mmol\/L; TBR<jats:sub>3.9<\/jats:sub>) and above (10.0\u00a0mmol\/L) the target glucose range (3.9\u201310.0 mmol\/L) were computed. TBR<jats:sub>3.9<\/jats:sub> \u22654% was defined as excessive hypoglycemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Type\u00a02 diabetes with a premixed or intensive insulin regimen had an increased %CV compared with those receiving oral therapy or basal insulin. The upper limit of %CV in group\u00a01 was 33%, which was adopted as the threshold to define excessive GV. For each treatment group, the percentage of people with TBR<jats:sub>3.9<\/jats:sub> \u22654% was significantly greater in the subgroup with %CV &gt;33% than \u226433% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In participants who achieved TBR<jats:sub>3.9<\/jats:sub> &lt;4%, the time per day spent within the target glucose range of 3.9\u201310.0\u00a0mmol\/L\u00a0&gt;\u00a070% and time per day above 10.0\u00a0mmol\/L &lt;25%, the 95th percentile of %CV was 32.70%. Further receiver operating characteristic curve analysis showed that the cut\u2010off values of %CV for predicting TBR<jats:sub>3.9<\/jats:sub> \u22654% varied by the type of diabetes and glycated hemoglobin categories.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A %CV of 33% was set as the threshold for excess glucose variability in Chinese diabetes patients. Meanwhile, glycated hemoglobin and the type of diabetes should be considered for the goal\u2010setting of %CV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13453","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T19:17:04Z","timestamp":1603999024000},"page":"1025-1034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Defining the target value of the coefficient of variation by continuous glucose monitoring in Chinese people with diabetes"],"prefix":"10.1111","volume":"12","author":[{"given":"Yifei","family":"Mo","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Clinical Center for Diabetes Shanghai Key Clinical Center for Metabolic Disease Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes Mellitus Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital Shanghai 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