{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T07:43:56Z","timestamp":1771919036743,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A severe complication associated with diabetes is diabetic foot ulcer (DFU). Most patients with DFU require amputation. Although treatment of non\u2010healing diabetic ulcers is challenging, the use of novel therapies can be effective. In this report, we present the case of a woman with type\u00a02 diabetes with DFU\u2010related osteomyelitis, who was treated with a combination therapy of trichloroacetic acid, calcium alginate and foam dressings, human autologous fibroblast injection, and a fibroblast cell\u2010seeded collagen scaffold. The results showed the positive effects of combination therapy on DFU. In the initial treatment, the wound area was measured to be 14\u00a0\u00d7\u00a07\u00a0cm<jats:sup>2<\/jats:sup>, with a depth of 4\u00a0cm. After 6\u00a0months, the wound was measured to be 1.5\u00a0cm<jats:sup>2<\/jats:sup>, showing a 90% reduction of the wound area. Overall, this combination therapy was highly effective in the treatment of DFU\u2010related osteomyelitis, and could markedly prevent amputation among DFU patients.<\/jats:p>","DOI":"10.1111\/jdi.13454","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T15:45:04Z","timestamp":1603986304000},"page":"1112-1117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Combination therapy of trichloroacetic acid, human autologous fibroblast injection and fibroblast seeded microfibrous collagen scaffold as a novel treatment for osteomyelitis diabetic foot ulcer"],"prefix":"10.1111","volume":"12","author":[{"given":"Mohammad Ali","family":"Nilforoushzadeh","sequence":"first","affiliation":[{"name":"Skin and Stem Cell Research Center Tehran University of Medical Sciences Tehran Iran"},{"name":"Jordan Dermatology and Hair Transplantation Center Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Heidari\u2010Kharaji","sequence":"additional","affiliation":[{"name":"Skin and Stem Cell Research Center Tehran University of Medical Sciences Tehran Iran"},{"name":"Jordan Dermatology and Hair Transplantation Center Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrak","family":"Zare","sequence":"additional","affiliation":[{"name":"Skin and Stem Cell Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sona","family":"Zare","sequence":"additional","affiliation":[{"name":"Skin and Stem Cell Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Batool","family":"Baiat Tork","sequence":"additional","affiliation":[{"name":"Skin and Stem Cell Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5326-0266","authenticated-orcid":false,"given":"Fariba","family":"Jaffary","sequence":"additional","affiliation":[{"name":"Skin and Stem Cell Research Center Tehran University of Medical Sciences Tehran Iran"},{"name":"Skin Diseases and Leishmaniasis Research Center (SDLRC) Isfahan University of Medical Sciences Isfahan Iran"},{"name":"Medical Education Research Center Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,23]]},"reference":[{"key":"e_1_2_6_2_1","article-title":"The quality of life in patients with diabetic foot ulcers","volume":"11","author":"Arshad M","year":"2020","journal-title":"J Diab Metab"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2017.26.Sup4.S4"},{"key":"e_1_2_6_4_1","first-page":"1","article-title":"Treatment of recalcitrant diabetic ulcers using trichloroacetic acid","volume":"17","author":"Nilforoushzadeh MA","year":"2012","journal-title":"J Res Med Sci"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.172905"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110078100200202"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2004.01375.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.17795\/jssc23312"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3923\/ijp.2006.633.636"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12884"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2011.12.011"},{"key":"e_1_2_6_12_1","first-page":"138","article-title":"Does cell therapy and tissue engineering represent a promising treatment of diabetic foot ulcers","volume":"111","author":"Ulicna M","year":"2010","journal-title":"Bratisl Lek Listy"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1701"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.4137\/CTTT.S3779"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.1998.4.403"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2006.00182.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2014.23.11.521"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","DOI":"10.5070\/D3228032089","article-title":"Comparing the efficacies of alginate, foam, hydrocolloid, hydrofiber, and hydrogel dressings in the management of diabetic foot ulcers and venous leg ulcers: a systematic review and meta\u2010analysis examining how to dress for success","volume":"22","author":"Saco M","year":"2016","journal-title":"Dermatol Online J"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","unstructured":"RahmaniS MooneyDJ.Tissue\u2010Engineered Wound Dressings for Diabetic Foot Ulcers.The Diabetic Foot:Springer 2018; 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