{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:24:04Z","timestamp":1778271844277,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T00:00:00Z","timestamp":1607817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Patients with type\u00a02 diabetes mellitus have a higher bone fracture risk than patients without diabetes. Although denosumab (Dmab) is a potent bone resorption inhibitor, its efficacy in patients with type\u00a02 diabetes mellitus has not been elucidated. In this study, we investigated the effects of switching to Dmab from bisphosphonates (BP) or a selective estrogen receptor modulator (SERM) in postmenopausal type\u00a02 diabetes mellitus patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This was a three medical institutions, prospective, observational study for postmenopausal patients with type\u00a02 diabetes mellitus whose T\u2010score of femoral neck or lumbar spine bone mineral density was under \u22121.0 standard deviation, even after &gt;6\u00a0months of BP or SERM administration. After obtaining consent, participants were treated for osteopenia\/osteoporosis by either continuing BP (BP\u2010BP group)\/SERM (SERM\u2010SERM group), or by switching to Dmab (BP\u2010Dmab or SERM\u2010Dmab groups). Changes in bone mineral density and bone metabolism marker levels were evaluated after 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 48 patients were included in this study, and each group comprised 12 patients. No significant difference existed in baseline characteristics among the groups. The average age and glycated hemoglobin were 71\u00a0\u00b1\u00a08\u00a0years and 7.2\u00a0\u00b1\u00a00.9%, respectively. In the SERM\u2010Dmab group, lumbar spine bone mineral density was significantly increased by 5.0% compared with the SERM\u2010SERM group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.04). Serum bone\u2010specific alkaline phosphatase and tartrate\u2010resistant acid phosphatase\u00a05b were significantly decreased in the BP\u2010Dmab and SERM\u2010Dmab groups compared with the BP\u2010BP and SERM\u2010SERM groups, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Switching to Dmab from BP or SERM is beneficial to prevent osteoporosis progression in postmenopausal patients with type\u00a02 diabetes mellitus patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13458","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T16:50:39Z","timestamp":1604422239000},"page":"1293-1300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Beneficial effects of switching to denosumab from bisphosphonates or selective estrogen receptor modulators in postmenopausal women with type\u00a02 diabetes and osteopenia\/osteoporosis"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5839-7448","authenticated-orcid":false,"given":"Arina","family":"Miyoshi","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology Sapporo City General Hospital Sapporo Japan"},{"name":"Department of Rheumatology, Endocrinology and Nephrology Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1870-6688","authenticated-orcid":false,"given":"Hiraku","family":"Kameda","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So","family":"Nagai","sequence":"additional","affiliation":[{"name":"Sapporo Medical Center NTT EC Sapporo 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Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Atsumi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5909-3243","authenticated-orcid":false,"given":"Hideaki","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Obesity Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,13]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Osteoporosis Prevention and Treatment Guidelines 2015 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