{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:27:09Z","timestamp":1788272829670,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T00:00:00Z","timestamp":1617408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Type\u00a01 diabetes is associated with poorer bone quality. Quantitative ultrasound provides an estimate of bone mineral density (BMD) and can also be used to evaluate bone quality, which is associated with an increased fracture risk in people with type\u00a01 diabetes. The aim of this study was to evaluate the association between menopausal status and a bone turnover marker with heel BMD using quantitative ultrasound in women with type\u00a01 diabetes and age\u2010 and body mass index\u2010matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 124 individuals recruited in Kyoto and Osaka, Japan \u2013 62 women with type\u00a01 diabetes (mean age 47.2\u00a0\u00b1\u00a017.3\u00a0years) and 62 age\u2010, menopausal status\u2010, sex\u2010 and body mass index\u2010matched non\u2010diabetic control individuals (mean age 47.3\u00a0\u00b1\u00a016.3\u00a0years) \u2013 were enrolled in this study. Heel BMD in the calcaneus was evaluated using ultrasonography (AOS\u2010100NW, Hitachi\u2010Aloka Medical, Ltd., Tokyo, Japan). A bone turnover marker was also measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The heel BMD Z\u2010score was significantly lower in premenopausal women with type\u00a01 diabetes than in the premenopausal control group, but not in postmenopausal women with type\u00a01 diabetes. Levels of tartrate\u2010resistant acid phosphatase\u20105b, a bone resorption marker, were significantly higher in premenopausal women with type\u00a01 diabetes than in the premenopausal control group, but not in postmenopausal women with type\u00a01 diabetes. The whole parathyroid hormone level was significantly lower in both pre\u2010 and postmenopausal women with type\u00a01 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lower heel BMD, higher tartrate\u2010resistant acid phosphatase\u20105b level and lower parathyroid hormone were observed in premenopausal women with type\u00a01 diabetes. Premenopausal women with type\u00a01 diabetes require osteoporosis precautions for postmenopause.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13530","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T06:27:43Z","timestamp":1613975263000},"page":"1689-1696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lower bone mineral density and higher bone resorption marker levels in premenopausal women with type\u00a01 diabetes in Japan"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3381-484X","authenticated-orcid":false,"given":"Fumi","family":"Yoshioka","sequence":"first","affiliation":[{"name":"Division of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Medical Center Kyoto Japan"},{"name":"Department of Internal Medicine Kawachi General Hospital Higashi\u2010Osaka Japan"},{"name":"Medical Corporation Makotokai Yoshioka Medical Clinic Kadoma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Nirengi","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Medical Center Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8634-9657","authenticated-orcid":false,"given":"Takashi","family":"Murata","sequence":"additional","affiliation":[{"name":"Diabetes Center National Hospital Organization Kyoto Medical Center Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaeko","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Medical Center Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomokazu","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Diabetes Center National Hospital Organization Kyoto Medical Center Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunio","family":"Saeki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kawachi General Hospital Higashi\u2010Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muneto","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Medical Corporation Makotokai Yoshioka Medical Clinic Kadoma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1881-067X","authenticated-orcid":false,"given":"Naoki","family":"Sakane","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Medical Center Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-016-0752-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-015-0284-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3882"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0253-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12734"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-014-0202-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-4097-x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-2426"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2017.06.018"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4749619"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-007-9082-5"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.02.019"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03187.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.091006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2018.07.012"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10396-017-0814-5"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.72.859.10624327"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.12.016"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.65.102"},{"key":"e_1_2_7_22_1","first-page":"639","article-title":"Dietary intake in body mass index differences in community\u2010based Japanese patients with Schizophrenia","volume":"44","author":"Ito H","year":"2015","journal-title":"Iran J Public Health"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-019-00996-z"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20110003"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2627"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-008-0763-3"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.29.02.06.dc05-1353"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2008.02608.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00850"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.2114\/jpa2.27.295"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-016-0227-2"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-00042"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-013-2372-z"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-019-01334-5"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.19344"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu5083022"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-018-4517-6"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.4.605"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5496710"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ16-0548"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1990.144"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.27423"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-017-0224-0"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00021"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S156350"},{"key":"e_1_2_7_46_1","first-page":"303","article-title":"Serum tartrate resistant acid phosphatase 5b in beta Thalassemia Egyptian patients: promising biomarker of iron overload oxidative stress and bone disease","volume":"7","author":"El\u2010Kaream SAA","year":"2019","journal-title":"Ann Clin Lab Res"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.894347"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0544-4"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/174186"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2001.14.5.525"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03351073"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S254885"},{"key":"e_1_2_7_53_1","first-page":"220","article-title":"Nutrient and dietary patterns in relation to the pathogenesis of postmenopausal osteoporosis\u2010A literature review","volume":"10","author":"Ilesanmi\u2010Oyelere BL","year":"2020","journal-title":"Life (Basel)"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.2.303"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3692-6"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-004-0553-8"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030743"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-003-0083-8"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2014.12.064"},{"key":"e_1_2_7_60_1","article-title":"Identification of 613 new loci associated with calcaneal bone mineral density and a polygenic risk score for bone mineral density, osteoporosis and fracture","volume":"13","author":"Kim SK","year":"2018","journal-title":"PLoS One"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.13530","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdi.13530","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.13530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T08:23:57Z","timestamp":1718094237000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.13530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,3]]},"references-count":59,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/jdi.13530"],"URL":"https:\/\/doi.org\/10.1111\/jdi.13530","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,3]]},"assertion":[{"value":"2020-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}