{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:04:49Z","timestamp":1791144289607,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>To examine the prevalence of falls and fractures, and the association with symptoms of diabetic polyneuropathy (DPN) in patients with recently diagnosed type\u00a02 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A detailed questionnaire on neuropathy symptoms and falls was sent to 6,726 patients enrolled in the Danish Center for Strategic Research in Type\u00a02 Diabetes cohort (median age 65\u00a0years, diabetes duration 4.6\u00a0years). Complete data on fractures and patient characteristics were ascertained from population\u2010based health registries. We defined possible DPN as a score \u22654 on the Michigan Neuropathy Screening Instruments questionnaire. Using Poisson regression analyses, we estimated the adjusted prevalence ratio (aPR) of falls and fractures, comparing patients with and without DPN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 5,359 patients (80%) answered the questions on the Michigan Neuropathy Screening Instruments questionnaire and falls. Within the year preceding the questionnaire response, 17% (<jats:italic>n<\/jats:italic>\u00a0=\u00a0933) reported at least one fall and 1.4% (<jats:italic>n<\/jats:italic>\u00a0=\u00a076) suffered from a fracture. The prevalence ratio of falls was substantially increased in patients with possible DPN compared with those without (aPR 2.33, 95% confidence interval [CI] 2.06\u20132.63). The prevalence ratio increased with the number of falls from aPR 1.51 (95% CI 1.22\u20131.89) for one fall to aPR 5.89 (95% CI 3.84\u20139.05) for four or more falls within the preceding year. Possible DPN was associated with a slightly although non\u2010significantly increased risk of fractures (aPR 1.32, 95% CI 0.75\u20132.33).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with recently diagnosed type\u00a02 diabetes and symptoms of DPN had a highly increased risk of falling. These results emphasize the need for preventive interventions to reduce fall risk among patients with type\u00a02 diabetes and possible DPN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13542","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T07:01:06Z","timestamp":1615273266000},"page":"1827-1834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Falls and fractures associated with type\u00a02 diabetic polyneuropathy: A cross\u2010sectional nationwide questionnaire study"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1288-6227","authenticated-orcid":false,"given":"Karolina Snopek","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine International Diabetic Neuropathy Consortium Aarhus University Aarhus Denmark"},{"name":"Department of Neurology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Hedevang","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine International Diabetic Neuropathy Consortium Aarhus University Aarhus Denmark"},{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sia Kromann","family":"Nicolaisen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Sif","family":"Gylfadottir","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine International Diabetic Neuropathy Consortium Aarhus University Aarhus Denmark"},{"name":"Department of Clinical Medicine Danish Pain Research Center Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3487-6380","authenticated-orcid":false,"given":"Troels Staehelin","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine International Diabetic Neuropathy Consortium Aarhus University Aarhus Denmark"},{"name":"Department of Clinical Medicine Danish Pain Research Center Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Steen","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine International Diabetic Neuropathy Consortium Aarhus University Aarhus Denmark"},{"name":"The Danish Center for Strategic Research in Type\u00a02 Diabetes Steno Diabetes Center Odense Odense University Hospital Odense Denmark"},{"name":"Research Unit of SDCO Department of Clinical Research University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9135-3474","authenticated-orcid":false,"given":"Reimar Wernich","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine International Diabetic Neuropathy Consortium Aarhus University Aarhus Denmark"},{"name":"Department of Neurology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2014.09.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afw140"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6537a2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp020719"},{"key":"e_1_2_6_6_1","first-page":"358","article-title":"Older individuals with diabetes have an increased risk of recurrent falls: analysis of potential mediating factors : the Longitudinal Ageing Study Amsterdam","volume":"30","author":"Health M","year":"2012","journal-title":"Age Ageing"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/50A.4.M211"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.05.032"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0429"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.55095\/achot2017\/003","article-title":"Delayed fracture healing in diabetics with distal radius fractures","volume":"84","author":"Pscherer S","year":"2017","journal-title":"Acta Chir Orthop Traumatol Cech"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2016.10.021"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1303"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.17.12.1411"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-017-0295-y"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154654"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.6.1543"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.10.1749"},{"key":"e_1_2_6_18_1","first-page":"721","article-title":"Diabetic polyneuropathy and risk of falls: fear of falling and other factors","volume":"56","author":"Bokan\u2010Mirkovic\u0301 V","year":"2017","journal-title":"Acta Clin Croat"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067055"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2009.02914.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01593"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04222.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080323"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/09638288.2013.770079"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-007-9082-5"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ17-0011"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S30838"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-017273"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001744"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11556-011-0078-9"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/09638288.2012.751136"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-1152"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.11.1983"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orcp.2015.02.006"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-1786-3"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3002"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0253-4"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S131945"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-014-0202-7"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00106"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.afos.2019.05.001"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2012.03644.x"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-2277"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.13542","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdi.13542","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.13542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T09:30:27Z","timestamp":1693128627000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.13542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,3]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/jdi.13542"],"URL":"https:\/\/doi.org\/10.1111\/jdi.13542","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,3]]},"assertion":[{"value":"2020-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}