{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:12:20Z","timestamp":1792674740603,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Introduction<\/jats:title>\n                    <jats:p>We aimed to examine the association between diabetes\u2010related parameters and hippocampal and parahippocampal gyrus atrophy (HPGA) in patients with type\u00a02 diabetes mellitus to elucidate the risk factors for HPGA, which is often accompanied by Alzheimer\u2019s disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A total of 137 patients aged \u226550\u00a0years with type\u00a02 diabetes mellitus (mean age 67.8\u00a0\u00b1\u00a09.8\u00a0years) underwent brain magnetic resonance imaging scans and comprehensive health examinations. We measured the volume of interest \u2013 a portion of the inner temporal lobe that includes the hippocampus, amygdala and entorhinal cortex (frontal part of the parahippocampal gyrus) \u2013 using the voxel\u2010based specific regional analysis system for Alzheimer\u2019s disease in each patient. The diabetes\u2010related parameters included glycated hemoglobin, fasting plasma glucose, C\u2010peptide (CPR) index (serum CPR\u00a0\/\u00a0fasting plasma glucose\u00a0\u00d7\u00a0100) and duration of diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean glycated hemoglobin was 9.3\u00a0\u00b1\u00a02.2%, the median CPR index was 1.29 (interquartile range 0.85\u20131.74) and the median duration of diabetes was 10\u00a0years (interquartile range 3\u201320\u00a0years). The severity score of volume of interest atrophy was &gt;1.0 in 36 patients. Using multivariate logistic regression analysis, we found that age (odds ratio 1.09, 95% confidence interval 1.02\u20131.15) and CPR index (odds ratio 0.451, 95% confidence interval 0.216\u20130.940) were significantly associated with HPGA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lower insulin secretion was significantly associated with HPGA in patients with type\u00a02 diabetes mellitus. The results of this study support the hypothesis that insulin\u2010signaling abnormalities are involved in the pathophysiology of Alzheimer\u2019s disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.13554","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T05:47:21Z","timestamp":1617083241000},"page":"1908-1913","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Lower insulin secretion is associated with hippocampal and parahippocampal gyrus atrophy in elderly patients with type\u00a02 diabetes mellitus"],"prefix":"10.1111","volume":"12","author":[{"given":"Yuko","family":"Adachi","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology Yokohama City Minato Red Cross Hospital Yokohama 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