{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:44:35Z","timestamp":1787161475177,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,6,6]],"date-time":"2021-06-06T00:00:00Z","timestamp":1622937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Introduction<\/jats:title>\n                    <jats:p>The relationship between glycated hemoglobin (HbA1c) and cardiovascular events in older adults was investigated using a Japanese administrative medical database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Anonymized medical data on patients with diabetes mellitus aged \u226565\u2009years for the period from January 2010 to December 2019 were extracted from the EBM Provider database. The primary end\u2010point was a composite of cardiovascular events, whereas the other end\u2010points included severe hypoglycemia and fracture. The association between cardiovascular events and HbA1c at the index date (i.e., approximately 10\u2009months after initial diabetes mellitus diagnosis) was evaluated using the Cox proportional hazards model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 3,186,751 patients in the database, 3,946 older adults with diabetes mellitus were eligible for inclusion and were subsequently grouped according to HbA1c quartiles at the index date. Cardiovascular events occurred in 142 patients. Patients with HbA1c in the highest quartile had significantly higher risk of hospitalization for cardiovascular disease than those with HbA1c in the lowest quartile (hazard ratio 1.948; 95% confidence interval 1.252\u20133.031,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003). However, the events risk was similar across subgroups with HbA1c &lt;7.2%. The incidence of hypoglycemia and fracture was not significantly associated with the level of glycemic control.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among older adults with diabetes mellitus, those with poor glycemic control were at higher risk for cardiovascular events compared with those with better glycemic control. However, strict glycemic control had no effect on cardiovascular risk in patients with HbA1c &lt;7.2%.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.13575","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T09:06:11Z","timestamp":1620983171000},"page":"2036-2045","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association between glycemic control and cardiovascular events in older Japanese adults with diabetes mellitus: An analysis of the Japanese medical administrative database"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3033-4813","authenticated-orcid":false,"given":"Koutaro","family":"Yokote","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Hematology, and Gerontology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2965-6906","authenticated-orcid":false,"given":"Ryo","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Metabolism and Endocrinology Tokyo Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2722-5202","authenticated-orcid":false,"given":"Maki","family":"Gouda","sequence":"additional","affiliation":[{"name":"Data Science Department Mitsubishi Tanabe Pharma Corporation Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4621-2394","authenticated-orcid":false,"given":"Hiroaki","family":"Iijima","sequence":"additional","affiliation":[{"name":"Medical Affairs Department Mitsubishi Tanabe Pharma Corporation Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Data Science Department Mitsubishi Tanabe Pharma Corporation Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Inagaki","sequence":"additional","affiliation":[{"name":"Data Science Department Mitsubishi Tanabe Pharma Corporation Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12333"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-1801"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0020"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.12956"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2681-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61969-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2011.00809.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2011.00808.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13340-018-0345-3"},{"key":"e_1_2_7_11_1","unstructured":"Survey of Japanese databases in Japan available for clinical\/pharmacoepidemiology. 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