{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:26:43Z","timestamp":1760218003227,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dipeptidyl peptidase\u20104 (DPP\u20104), namely CD26, is expressed on the surface of immune cells, suggesting that inhibition of DPP\u20104 might affect the immune system. The current multicenter observational case\u2013control study was carried out to investigate the effects of DPP\u20104 inhibitor (DPP\u20104i) administration on Graves' disease (GD) activity. This study comprised patients with GD and type\u20092 diabetes, who were administered an oral hypoglycemic agent including DPP\u20104i. Exacerbation of GD was defined as an increase of antithyroid drug dose by 6\u2009months after oral hypoglycemic agent administration. A total of 80 patients were enrolled and divided into an exacerbation group or a non\u2010exacerbation group. The frequency of DPP\u20104i administration was significantly higher in the exacerbation group (88%) than that in the non\u2010exacerbation group (31%). In multivariate logistic regression analysis, there was a significant association between DPP\u20104i administration and GD exacerbation (odds ratio 7.39). The current study suggests that DPP\u20104i administration is associated with GD exacerbation.<\/jats:p>","DOI":"10.1111\/jdi.13578","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T09:51:21Z","timestamp":1621245081000},"page":"1978-1982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dipeptidyl peptidase\u20104 inhibitor might exacerbate Graves\u2019 disease: A multicenter observational case\u2013control study"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6218-5819","authenticated-orcid":false,"given":"Tomonori","family":"Sekizaki","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1870-6688","authenticated-orcid":false,"given":"Hiraku","family":"Kameda","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0713-221X","authenticated-orcid":false,"given":"Hiroshi","family":"Nomoto","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3131-0832","authenticated-orcid":false,"given":"Kyu Yong","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan"},{"name":"Clinical Research and Medical Innovation Center Hokkaido University Hospital Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8192-0006","authenticated-orcid":false,"given":"Akinobu","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3962-4078","authenticated-orcid":false,"given":"Kiyohiko","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Sapporo City General Hospital Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5839-7448","authenticated-orcid":false,"given":"Arina","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Sapporo City General Hospital Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Sapporo City General Hospital Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Sapporo Diabetes and Thyroid Clinic Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Sapporo Medical Center NTT East Corporation Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5909-3243","authenticated-orcid":false,"given":"Hideaki","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan"},{"name":"Division of Diabetes and Obesity Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Atsumi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00389"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1998.tb01571.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.7592"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12695"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k872"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-018-9005-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1555762"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12119"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205216"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2741\/2960"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2741\/3193"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-011-0137-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2013.879862"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8431838"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03778.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2015.10.012"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.13578","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdi.13578","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.13578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T11:53:03Z","timestamp":1693223583000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.13578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,16]]},"references-count":16,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/jdi.13578"],"URL":"https:\/\/doi.org\/10.1111\/jdi.13578","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"type":"print","value":"2040-1116"},{"type":"electronic","value":"2040-1124"}],"subject":[],"published":{"date-parts":[[2021,6,16]]},"assertion":[{"value":"2020-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}