{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T17:59:58Z","timestamp":1757699998318,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T00:00:00Z","timestamp":1626480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872718"],"award-info":[{"award-number":["81872718"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014175","name":"Shanghai Municipal Health and Family Planning Commission","doi-asserted-by":"publisher","award":["201840041"],"award-info":[{"award-number":["201840041"]}],"id":[{"id":"10.13039\/501100014175","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Few people have reported whether there are sex differences in blood lipids and lipid ratios in type\u20092 diabetic foot (T2DF) patients in China. This study attempts to identify the contribution to sex\u2010specific differences in blood lipids and lipid ratios in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this case\u2013control study, we explore 306 patients with T2DF as the study group and 306 patients with type\u20092 diabetes mellitus as the control group. Patients were diagnosed according to the Standards of Medical Care in Diabetes\u20132014 (American Diabetes Association). Blood lipid and lipid ratios were determined according to the National Cholesterol Education Program Adult Treatment Panel\u00a0III criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We studied male patients with T2DF who were aged 68.00\u2009years (18.00\u2009years) and females who were aged 73.50\u2009years (19.00\u2009years); 61.76% of the patients were men. Men had higher body mass index and glycated hemoglobin levels than women. Compared with type\u20092 diabetes mellitus patients, T2DF patients had significant differences in total cholesterol\/high\u2010density lipoprotein cholesterol (HDL\u2010C), low\u2010density lipoprotein cholesterol\/HDL\u2010C and apolipoprotein (apo)B\/apoA\u2010I ratios. HDL\u2010C, triglyceride, apoA\u2010I and apoB\/apoA\u2010I ratio showed cardiovascular disease risk in men, whereas total cholesterol, low\u2010density lipoprotein cholesterol, apoB, and the low\u2010density lipoprotein cholesterol\/HDL\u2010C and total cholesterol\/HDL\u2010C ratios were better predictors in women. The apoB\/apoA\u2010I ratio odds ratio values were 2.18 (95% confidence interval 1.17\u20134.41) and 2.14 (95% confidence interval 1.14\u20134.00) in male patients with T2DF before and after adjusting for age, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>T2DF patients present sex\u2010specific differences in their blood lipid and lipid ratios, especially in the apoB\/apoA\u2010I ratio, which could be a better indicator for cardiovascular disease risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13615","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T11:21:18Z","timestamp":1623756078000},"page":"2203-2211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sex\u2010specific differences in blood lipids and lipid ratios in type\u20092 diabetic foot patients"],"prefix":"10.1111","volume":"12","author":[{"given":"Shuming","family":"Yin","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Huadong Hospital Affiliated to Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Division of Respiration Department of Medicine Shanghai Traditional Chinese Medicine Integrated Hospital Affiliated to Shanghai Traditional Chinese Medicine University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6264-0965","authenticated-orcid":false,"given":"Zisheng","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics School of Medicine Tongji University Shanghai China"},{"name":"Shanghai Pudong New Area Mental Health Center School of Medicine Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Deng","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Longhua Hospital Affiliated to Shanghai Traditional Chinese Medicine University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Jia","sequence":"additional","affiliation":[{"name":"Division of Respiration Department of Medicine Shanghai Traditional Chinese Medicine Integrated Hospital Affiliated to Shanghai Traditional Chinese Medicine University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics School of Medicine Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics School of 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