{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:26:33Z","timestamp":1792419993721,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Type\u20092 diabetes mellitus is associated with an increased incidence of osteoporosis and sarcopenia. However, the relationship between osteoporosis and sarcopenia in patients with type\u20092 diabetes mellitus remains to be unclear. Appendicular skeletal muscle was adjusted by height (appendicular skeletal muscle mass [ASM]\/height<jats:sup>2<\/jats:sup>) as a marker of sarcopenia. This study aimed to explore the relationship between ASM\/height<jats:sup>2<\/jats:sup>, osteoporosis and bone mineral density (BMD) in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 192 women and 225 men with type\u20092 diabetes mellitus were recruited. General information, laboratory and BMD data were collected. Spearman\u2019s correlation, multiple regression analyses and receiver operating characteristic curve analysis were used to explore the correlation between ASM\/height<jats:sup>2<\/jats:sup>, BMD and bone metabolism markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Spearman\u2019s correlation analysis showed that ASM\/height<jats:sup>2<\/jats:sup> had a positive correlation with serum calcium and BMD (<jats:italic>r<\/jats:italic>\u2009=\u20090.209\u20130.404, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). In multivariate regression analysis, we found significant correlations between ASM\/height<jats:sup>2<\/jats:sup> and total lumbar spine, hip and femur neck BMD. According to the receiver operating characteristic curve, ASM\/height<jats:sup>2<\/jats:sup> was the best marker of osteoporosis, with a cut\u2010off value of 7.87\u2009kg\/m<jats:sup>2<\/jats:sup> for men and 5.94\u2009kg\/m<jats:sup>2<\/jats:sup> for women. When these cut\u2010off values were used to identify sarcopenia, the risk of osteoporosis increased 6.036\u2010fold in men and 4.079\u2010fold in women, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with type\u20092 diabetes mellitus, ASM\/height<jats:sup>2<\/jats:sup> was positively correlated with BMD, and negatively correlated with osteoporosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13642","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T06:52:45Z","timestamp":1627973565000},"page":"351-358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Association between muscle mass, bone mineral density and osteoporosis in type\u20092 diabetes"],"prefix":"10.1111","volume":"13","author":[{"given":"Youjin","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6785-9846","authenticated-orcid":false,"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1017","article-title":"Epidemiology and management of osteoporosis in the People's Republic of China: current perspectives","volume":"10","author":"Lin X","year":"2015","journal-title":"Clin Interv 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