{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:21:25Z","timestamp":1774585285823,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Subcutaneous insulin resistance syndrome is a rare condition that causes difficulty in glycemic control due to severe resistance to subcutaneous insulin injections. We herein present a case of a 40\u2010year\u2010old woman with type\u20092 diabetes mellitus who had been diagnosed with subcutaneous insulin resistance syndrome since the age of 29\u2009years, and had been persistently treated with continuous subcutaneous insulin infusion using a mixture of insulin lispro and heparin. The patient was switched from insulin lispro plus heparin to ultra\u2010rapid insulin lispro; given that it contains treprostinil and citrate, it is expected to have similar effects as heparin, and shows similar glucose\u2010lowering effects and insulin absorption. Our results suggest that treatment with ultra\u2010rapid insulin lispro is effective for subcutaneous insulin resistance syndrome.<\/jats:p>","DOI":"10.1111\/jdi.13667","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T17:27:31Z","timestamp":1631467651000},"page":"588-591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Case of subcutaneous insulin resistance syndrome treated with ultra\u2010rapid insulin lispro"],"prefix":"10.1111","volume":"13","author":[{"given":"Takahiro","family":"Ishii","sequence":"first","affiliation":[{"name":"Department of Diabetology and Metabolism Okayama Medical Center National Hospital Organization Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9729-7343","authenticated-orcid":false,"given":"Akihiro","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Metabolism Okayama Medical Center National Hospital Organization Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihiro","family":"Sue","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Metabolism Okayama Medical Center National Hospital Organization Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remi","family":"Kuribayashi","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Metabolism Okayama Medical Center National Hospital Organization Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Tenta","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Metabolism Okayama Medical Center National Hospital Organization Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of 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