{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:58:26Z","timestamp":1792252706755,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18H04126"],"award-info":[{"award-number":["18H04126"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K17390"],"award-info":[{"award-number":["18K17390"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Introduction<\/jats:title>\n                    <jats:p>We assessed the association between dipeptidyl peptidase\u20104 inhibitors (DPP\u20104is) and bullous pemphigoid (BP) and time\u2010dependent changes in the risk for developing BP after DPP\u20104i initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The present population\u2010based, real\u2010world study was carried out using the Japanese National Database dataset collected between 2013 and 2018. To assess independent correlations between DPP\u20104is and the development of BP, the self\u2010controlled case series method was used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the cohort followed up for a median of 1,540\u2009days, 53,027 patients were likely to develop BP. The possible incidence rate of BP in all 150,328,339 patients was 10.4\/100,000 person\u2010years. Among the 9,705,814 patients with type\u20092 diabetes, 15,634 were likely to develop BP. The possible incidence rate of BP in patients with type\u20092 diabetes was 38.1\/100,000 person\u2010years, whereas that in patients with type\u20092 diabetes who did and did not use DPP\u20104is was 40.7 and 30.0\/100,000 person\u2010years, respectively. Analysis of the 28,705 patients with type\u20092 diabetes likely to develop BP after initial DPP\u20104i use showed a risk ratio of 2.15 (95% confidence interval [CI] 1.75\u20132.63), 1.70 (95% CI 1.37\u20132.11), 1.44 (95% CI 1.15\u20131.82), 1.25 (95% CI 0.98\u20131.59), 0.84 (95% CI 0.63\u20131.10), 0.84 (95% CI 0.64\u20131.11) and 1.05 (95% CI 0.92\u20131.20), for the risk period of \u226430, 31\u201360, 61\u201390, 91\u2013120, 121\u2013150, 151\u2013180 and 181\u2013365\u2009days, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although DPP\u20104is were associated with increased risk for BP, the risk was particularly significant within 3\u2009months from first use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.13676","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T11:31:37Z","timestamp":1632483097000},"page":"460-467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association between dipeptidyl peptidase\u20104 inhibitors and increased risk for bullous pemphigoid within 3\u2009months from first use: A 5\u2010year population\u2010based cohort study using the Japanese National Database"],"prefix":"10.1111","volume":"13","author":[{"given":"Hirohito","family":"Kuwata","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology Nara Medical University Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1956-3925","authenticated-orcid":false,"given":"Yuichi","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Nara Medical University Kashihara Japan"},{"name":"Department of Public health Health Management and Policy Nara Medical University Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Public health Health Management and Policy Nara Medical University Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Kubo","sequence":"additional","affiliation":[{"name":"Department of Public health Health Management and Policy Nara Medical University Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Myojin","sequence":"additional","affiliation":[{"name":"Department of Public health Health Management and Policy Nara Medical University Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuneyuki","family":"Higashino","sequence":"additional","affiliation":[{"name":"Healthcare and Wellness Division Mitsubishi Research Institute Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Nara Medical University Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Doctor\u2010Patient Relationships Nara Medical University Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Public health Health Management and Policy Nara Medical University Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010007\u20100030\u2010y"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14312"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.03.010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20103083.2011.04062.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.1073"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3315\/jdcr.2014.1166"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443330"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12695"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495\u2010200565030\u201000005"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079907X178766"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v7.i17.354"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01238"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13060"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JID.2018.01.027"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JID.2018.10.045"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11\u20100804"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.12.038"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.2352"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13100"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1101\/280008"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2302"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533328"},{"key":"e_1_2_7_24_1","unstructured":"Japan Intractable Diseases Information CenterAvailable from:https:\/\/www.nanbyou.or.jp\/entry\/5354Accessed October 3 2021"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19\u20100409"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.2158"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20103166"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.05.030"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.13676","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdi.13676","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.13676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T07:05:50Z","timestamp":1693119950000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.13676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,11]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/jdi.13676"],"URL":"https:\/\/doi.org\/10.1111\/jdi.13676","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,11]]},"assertion":[{"value":"2021-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}