{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:19:53Z","timestamp":1789510793929,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004166","name":"Warszawski Uniwersytet Medyczny","doi-asserted-by":"publisher","award":["1W51\/M\/MB1\/N\/20"],"award-info":[{"award-number":["1W51\/M\/MB1\/N\/20"]}],"id":[{"id":"10.13039\/501100004166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>The aim of the present study was to evaluate the placental expression of glucose transporters\u2009GLUT\u20101, GLUT\u20103, GLUT\u20108 and GLUT\u201012 in term pregnancies complicated by well\u2010controlled gestational (GDM) and type\u20091 pregestational diabetes mellitus (PGDM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 103 placental samples were obtained from patients diagnosed with GDM (<jats:italic>n<\/jats:italic>\u2009=\u200960), PGDM (<jats:italic>n<\/jats:italic>\u2009=\u200920) and a non\u2010diabetic control group (<jats:italic>n<\/jats:italic>\u2009=\u200923). Computer\u2010assisted quantitative morphometry of stained placental sections was performed to determine the expression of selected GLUT proteins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Immunohistochemical techniques used for the identification of GLUT\u20101, GLUT\u20103, GLUT\u20108 and GLUT\u201012 revealed the presence of all glucose transporters in the placental tissue. Morphometric evaluation performed for the vascular density\u2010matched placental samples demonstrated a significant increase in the expression of GLUT\u20101 protein in patients with PGDM as compared to GDM and control groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). With regard to the expression of the other GLUT isoforms, no statistically significant differences were observed between patients from the diabetic and control populations. Positive correlations between fetal birthweight and the expression of GLUT\u20101 protein in the PGDM group (rho\u2009=\u20090.463, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and GLUT\u201012 in the control group (rho\u2009=\u20090.481, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) were noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In term pregnancies complicated by well\u2010controlled GDM\/PGDM, expression of transporters GLUT\u20103, GLUT\u20108 and GLUT\u201012 in the placenta remains unaffected. Increased expression of GLUT\u20101 among women with type\u20091 PGDM might contribute to a higher rate of macrosomic fetuses in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13680","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T19:09:36Z","timestamp":1632424176000},"page":"560-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Placental expression of glucose transporters GLUT\u20101, GLUT\u20103, GLUT\u20108 and GLUT\u201012 in pregnancies complicated by gestational and type 1 diabetes mellitus"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7445-7546","authenticated-orcid":false,"given":"Pawe\u0142 Jan","family":"Stanirowski","sequence":"first","affiliation":[{"name":"1st Department of Obstetrics and Gynecology Medical University of Warsaw Warsaw 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