{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:59:37Z","timestamp":1761897577551,"version":"3.40.5"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T00:00:00Z","timestamp":1636243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2018YFC2001005"],"award-info":[{"award-number":["2018YFC2001005"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>We aimed to explore the clinical factors associated with glycemic variability (GV) assessed with flash glucose monitoring (FGM), and investigate the impact of FGM on glycemic control among Chinese type\u20091 diabetes mellitus patients in a real\u2010life clinical setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 171 patients were included. GV was assessed from FGM data. A total of 110 patients wore FGM continuously for 6\u2009months (longitudinal cohort). Hemoglobin A1c (HbA1c), fasting and 2\u2010h postprandial C\u2010peptide, and glucose profiles were collected. Changes in HbA1c and glycemic parameters were assessed during a 6\u2010month FGM period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Individuals with high residual C\u2010peptide (HRCP; 2\u2010h postprandial C\u2010peptide &gt;200\u2009pmol\/L) had less GV than patients with low residual C\u2010peptide ( 2\u2010h postprandial C\u2010peptide \u2264200\u2009pmol\/L; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In the longitudinal cohort (<jats:italic>n<\/jats:italic>\u2009=\u2009110), HbA1c and mean glucose decreased, time in range (TIR) increased during the follow\u2010up period (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The 110 patients were further divided into age and residual C\u2010peptide subgroups: (i) HbA1c and mean glucose were reduced significantly only in the subgroup aged \u226414\u2009years during the follow\u2010up period, whereas time below range also increased in this subgroup at 3\u2009months (<jats:italic>P\u2009=\u2009<\/jats:italic>0.047); and (ii) HbA1c improved in the HRCP subgroup at 3 and 6\u2009months (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The mean glucose decreased and TIR improved significantly in the low residual C\u2010peptide subgroup; however, TIR was still lower and time below range was higher than those of the HRCP subgroup at all time points (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HRCP was associated with less GV. FGM wearing significantly reduced HbA1c, especially in pediatric patients and those with HRCP. Additionally, the mean glucose and TIR were also found to improve.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13693","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:09:02Z","timestamp":1634083742000},"page":"552-559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of flash glucose monitoring on glycemic control varies with the age and residual <i>\u03b2<\/i>\u2010cell function of patients with type\u20091 diabetes mellitus"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8477-094X","authenticated-orcid":false,"given":"Liyin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Metabolism and Endocrinology National Clinical Research Center for Metabolic Diseases The Second Xiangya Hospital of Central South University Changsha 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