{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:46:06Z","timestamp":1787237166082,"version":"build-2736575974"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Interleukin\u20106 is a pleiotropic cytokine that plays a pathogenic role in type\u20091 diabetes. Therefore, anti\u2010interleukin\u20106 receptor antibody, tocilizumab, used for the treatment of rheumatoid arthritis, is considered a candidate for immune intervention in type\u20091 diabetes. Here, we report the case of a 73\u2010year\u2010old woman (HLA\u2010DR9\u2010DQ3 homozygote) with well\u2010controlled rheumatoid arthritis who developed type\u20091 diabetes while receiving tocilizumab treatment. At 57\u2009years\u2010of\u2010age, the patient was diagnosed with rheumatoid arthritis, for which she underwent tocilizumab therapy that enabled complete suppression of her joint inflammation. A total of 17 months after starting tocilizumab therapy, she noticed polydipsia, polyuria, general fatigue and weight reduction (\u22122\u2009kg\/month), and was diagnosed with type\u20091 diabetes with diabetic ketoacidosis based on an arterial pH of 7.26, serum ketone body of 7,437\u2009\u03bcmol\/L, blood glucose level of 925\u2009mg\/dL, glycated hemoglobin of 13.2% and the presence of anti\u2010islet autoantibodies. This case report shows valuable insight regarding the effect of anti\u2010interleukin\u20106 receptor antibody therapy on type\u20091 diabetes prevention.<\/jats:p>","DOI":"10.1111\/jdi.13706","type":"journal-article","created":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T01:14:42Z","timestamp":1636247682000},"page":"738-740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Development of type\u20091 diabetes in a patient treated with anti\u2010interleukin\u20106 receptor antibody for rheumatoid arthritis"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7434-4744","authenticated-orcid":false,"given":"Eiji","family":"Kawasaki","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology Shin\u2010Koga Hospital Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Fukuyama","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Shin\u2010Koga Hospital Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aira","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Shin\u2010Koga Hospital Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Sagara","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Shin\u2010Koga Hospital Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Shin\u2010Koga Hospital Kurume 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of Diabetes 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