{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:25:10Z","timestamp":1747185910661,"version":"3.40.5"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Here, we report a case of allogeneic islet transplantation in Japan. A 48\u2010year\u2010old man received intraportal islet transplantation (5,945 islet equivalent\/kg), and stabilization of blood glucose levels and suppression of hypoglycemia were achieved. In the present case, we used our original assessment method to detect the responses of the recipient\u2019s T\u2009cells to islet autoantigens over time to monitor cellular autoimmunity. Other markers could not predict graft dysfunction in advance, but our method detected the activation of islet antigen\u2010specific CD8<jats:sup>+<\/jats:sup> T\u2010cell responses before the deterioration of pancreatic \u03b2\u2010cell function, indicating the possibility of the non\u2010invasive detection of pancreatic \u03b2\u2010cell damage due to recurrent autoimmunity.<\/jats:p>","DOI":"10.1111\/jdi.13715","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T12:12:44Z","timestamp":1637237564000},"page":"741-745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Allogeneic islet transplantation with monitoring of islet\u2010specific cellular autoimmunity in a Japanese patient with type\u20091 diabetes: A case report"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7727-6310","authenticated-orcid":false,"given":"Daisuke","family":"Chujo","sequence":"first","affiliation":[{"name":"Pancreatic Islet Transplantation Project, Research Institute National Center for Global Health and Medicine Tokyo Japan"},{"name":"Department of Diabetes, Endocrinology and Metabolism National Center for Global health and Medicine Tokyo Japan"},{"name":"Center for Clinical Research Toyama University Hospital Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Kurokawa","sequence":"additional","affiliation":[{"name":"Department of Surgery JCHO Tokyo Takanawa Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akitsu","family":"Kawabe","sequence":"additional","affiliation":[{"name":"Pancreatic Islet Transplantation Project, Research Institute National Center for Global Health and Medicine Tokyo 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shotaro","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Tsukuba Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Edamoto","sequence":"additional","affiliation":[{"name":"Department of Surgery Secomedic Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Ohmagari","sequence":"additional","affiliation":[{"name":"Disease Control and Prevention Center National Center for Global Health and Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Hinoshita","sequence":"additional","affiliation":[{"name":"Nephrology National Center for Global Health and Medicine Tokyo 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Pancreatic Islet Transplantation Project, Research Institute National Center for Global Health and Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0338-0008","authenticated-orcid":false,"given":"Masayuki","family":"Shimoda","sequence":"additional","affiliation":[{"name":"Pancreatic Islet Transplantation Project, Research Institute National Center for Global Health and Medicine Tokyo 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