{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:11:09Z","timestamp":1790727069842,"version":"4.1.0"},"reference-count":113,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The global prevalence of non\u2010alcoholic fatty liver disease (NAFLD) is rising, along with the epidemic of diabesity. NAFLD is present in &gt;70% of individuals with type\u20092 diabetes. Although the mutually detrimental relationship between NAFLD and type\u20092 diabetes has been well established, a multitude of recent studies have further shown that type\u20092 diabetes is closely linked to the development of cirrhosis, hepatocellular carcinoma, liver\u2010related morbidity and mortality. In contrast, NAFLD also negatively impacts type\u20092 diabetes both in terms of its incidence and related adverse clinical outcomes, including cardiovascular and chronic kidney diseases. In response to these global health threats, clinical care pathways for NAFLD and guidelines for metabolic dysfunction\u2010associated fatty liver disease have been developed. Several antidiabetic agents have been evaluated for their potential hepatic benefits with promising results. Furthermore, type\u20092 diabetes patients are increasingly represented in clinical trials of novel therapeutics for NAFLD. However, despite the wealth of knowledge in NAFLD and type\u20092 diabetes, lack of awareness of the disease and the potential weight of this problem remains a major challenge, especially among clinicians who are outside the field of hepatology and gastroenterology. This review therefore aimed to provide all diabetes care providers with a summary of the latest evidence that supports NAFLD as an emerging diabetic complication of increasing importance, and to present the current recommendations, focusing on the assessment and therapeutic strategies, on the management of NAFLD among type\u20092 diabetes patients.<\/jats:p>","DOI":"10.1111\/jdi.13756","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T03:15:04Z","timestamp":1643166904000},"page":"930-940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Non\u2010alcoholic fatty liver disease and type\u20092 diabetes: An update"],"prefix":"10.1111","volume":"13","author":[{"given":"Chi\u2010H","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medicine University of Hong Kong  Hong Kong Hong Kong"},{"name":"State Key Laboratory of Pharmaceutical Biotechnology University of Hong Kong  Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9813-1126","authenticated-orcid":false,"given":"David TW","family":"Lui","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Hong Kong  Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5757-541X","authenticated-orcid":false,"given":"Karen SL","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Hong Kong  Hong Kong Hong Kong"},{"name":"State Key Laboratory of Pharmaceutical Biotechnology University of Hong Kong  Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30251"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.12.012"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00014-X"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.06.021"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.043"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27368"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29466"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-1113"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00523-4"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12725"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6638306"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.132"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31806"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13455"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.327"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.08.024"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30858"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1321-x"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322572"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154866"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.006"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00020-0"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00308-3"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-323082"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab425"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14274"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.05.003"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.09.020"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2019.11.004"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2020.03.004"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108358"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.039"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14548"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.10.046"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154299"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31518"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2014.01.005"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI134165"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12093"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986712803833173"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2016-1765"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12255-6"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036868"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31819e9048"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200317797"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22106-2"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.062463"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/89076"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.10.022"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.647503"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0413"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1379"},{"key":"e_1_2_15_56_1","article-title":"Circulating level of FABP4 is an independent predictor of metabolic dysfunction\u2010associated fatty liver disease in middle\u2010aged and elderly individuals","author":"Tanaka M","year":"2021","journal-title":"J Diabetes Investig"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.589206"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22896"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202003721"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.2337\/db19-0701"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.07.049"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-020-10094-2"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13857"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.07.050"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.11.004"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-S004"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29085"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.043"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2029349"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102021\u2010324243"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-019-01467-7"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-1071"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-1239"},{"key":"e_1_2_15_74_1","article-title":"Diabetes liver fibrosis score to detect advanced fibrosis in diabetics with nonalcoholic fatty liver disease","author":"Singh A","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14347"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2020.08.005"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-1997"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-1778"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-0131"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2020.887"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.05.016"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-S004"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00366-5"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.9607"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.12.001"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0167"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2036205"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(19)30249-9"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00803-X"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab578"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32260-8"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-1892"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-2151"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504720"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611925"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812389"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1911303"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1811744"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2022190"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2019.05.007"},{"issue":"4","key":"e_1_2_15_101_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.kint.2020.06.019","article-title":"KDIGO 2020 clinical practice guideline for diabetes management in chronic kidney disease","volume":"98","author":"Kidney Disease: Improving Global Outcomes Diabetes Work G","year":"2020","journal-title":"Kidney Int"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-019-5477-1"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174272"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13237"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13520"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.205088"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-018-9843-4"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31142"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154874"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.12.053"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00408-y"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1608664"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-2354"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30314-3"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.13756","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdi.13756","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.13756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T13:41:38Z","timestamp":1692625298000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.13756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,14]]},"references-count":113,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/jdi.13756"],"URL":"https:\/\/doi.org\/10.1111\/jdi.13756","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,14]]},"assertion":[{"value":"2022-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}