{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:25:20Z","timestamp":1747185920731,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>The present trial compared the efficacy and safety of once\u2010daily liraglutide 1.8\u2009mg with liraglutide 0.9\u2009mg in Japanese patients with type 2 diabetes to assess the incremental effects of liraglutide 1.8\u2009mg in those who exhibited an inadequate response to 0.9\u2009mg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This 26\u2010week randomized trial (NCT02505334) enrolled Japanese adults with type 2 diabetes across 47 sites in Japan. Participants with glycated hemoglobin (HbA<jats:sub>1c<\/jats:sub>) 7.5\u201310.0% were included and those on insulin treatment were excluded. Participants discontinued pre\u2010trial oral antidiabetic drug and initiated liraglutide 0.9\u2009mg for a 12\u2010week run\u2010in period, after which those with HbA<jats:sub>1c<\/jats:sub> \u22657.0% (466) were randomized (1:1) to two treatment arms: continuing liraglutide 0.9\u2009mg or dose escalation to 1.8\u2009mg. The change from baseline in HbA<jats:sub>1c<\/jats:sub> (primary endpoint) and treatment\u2010emergent adverse events (secondary endpoint) were measured at the end of 26\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 26\u2009weeks of treatment, liraglutide 1.8\u2009mg was more effective compared with 0.9\u2009mg in lowering HbA<jats:sub>1c<\/jats:sub> levels, with an estimated treatment difference of \u22120.40% (95% confidence interval [CI] \u22120.55, \u22120.24; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Liraglutide 1.8\u2009mg was associated with significantly greater odds of participants reaching HbA<jats:sub>1c<\/jats:sub> &lt;7.0% (estimated odds ratio [EOR] 3.87; 95% CI 2.12, 7.08; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) and \u22646.5% (EOR 3.78; 95% CI 1.36, 10.54; <jats:italic>P<\/jats:italic>\u2009=\u20090.0109) compared with 0.9\u2009mg. Both doses were well tolerated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Liraglutide 1.8\u2009mg had better efficacy in improving HbA<jats:sub>1c<\/jats:sub> levels after 26\u2009weeks treatment vs 0.9\u2009mg in Japanese patients, with both doses well tolerated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13789","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T06:49:52Z","timestamp":1647240592000},"page":"1321-1329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A randomized trial to investigate the efficacy and safety of once\u2010daily liraglutide 1.8\u2009mg in Japanese adults with type 2 diabetes exhibiting an inadequate response to liraglutide 0.9\u2009mg"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1099-7989","authenticated-orcid":false,"given":"Yutaka","family":"Seino","sequence":"first","affiliation":[{"name":"Kansai Electric Power Hospital  Osaka Japan"},{"name":"Kansai Electric Power Medical Research Institute  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5909-3243","authenticated-orcid":false,"given":"Hideaki","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Obesity Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidrun","family":"Bosch Traberg","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S  S\u00f8borg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T V S","family":"Divyalasya","sequence":"additional","affiliation":[{"name":"Novo Nordisk Service Centre India Private Ltd  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Nishijima","sequence":"additional","affiliation":[{"name":"Novo Nordisk Pharma Ltd  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Terauchi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-S002"},{"key":"e_1_2_7_3_1","unstructured":"Ministry of Health Labour and Welfare. 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