{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:24:37Z","timestamp":1789140277878,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Diabetes and sarcopenia have a two\u2010way relationship with each other with advanced age. Additionally, malnutrition is correlated with a higher risk of sarcopenia in elderly patients. This study evaluated the association between sarcopenia and geriatric nutritional risk index (GNRI) in elderly patients with type 2 diabetes mellitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Patients with type 2 diabetes mellitus aged \u226560\u2009years were recruited from June 2018 to August 2020. This study analyzed 234 patients, who completed a physical performance test required for the diagnosis of sarcopenia. To investigate the effect of GNRI on sarcopenia, logistic regression analyses was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with sarcopenia were significantly older with a lower body mass index (BMI) and GNRI compared with normal patients. The GNRI showed a positive correlation with the skeletal muscle index (SMI) and handgrip strength (SMI: <jats:italic>R<\/jats:italic>\u2009=\u20090.486, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 for male; <jats:italic>R<\/jats:italic>\u2009=\u20090.589, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 for female, handgrip strength: <jats:italic>R<\/jats:italic>\u2009=\u20090.470, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 for male, <jats:italic>R<\/jats:italic>\u2009=\u20090.364, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 for female). In the multivariate logistic regression model, a higher GNRI was associated with a lower risk of sarcopenia in older men and women with diabetes (adjusted odds ratio [OR], 0.892; 95% confidence interval [CI], 0.839\u20130.948 for male; adjusted OR, 0.928; 95% CI, 0.876\u20130.982 for female). One year of diabetes treatment improved the GNRI in the sarcopenia group with type 2 diabetes mellitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A low GNRI was associated with an increased risk of sarcopenia in elderly patients with type 2 diabetes mellitus. Treatment with glucose\u2010lowering drugs improved the GNRI in the sarcopenia group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13792","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T18:34:31Z","timestamp":1647369271000},"page":"1366-1373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Sarcopenia is associated with the Geriatric Nutritional Risk Index in elderly patients with poorly controlled type 2 diabetes mellitus"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8844-6100","authenticated-orcid":false,"given":"Shun","family":"Matsuura","sequence":"first","affiliation":[{"name":"Division of Diabetes Endocrinology Medicine Fujieda Municipal General Hospital  Fujieda Japan"},{"name":"Division of Respiratory Internal Medicine Fujieda Municipal General Hospital  Fujieda 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