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Although they show a similar action on glucose\u2010induced insulin secretion, two incretins are distinct in various aspects. GIP is secreted from enteroendocrine K\u2009cell mainly expressed in the upper small intestine, and GLP\u20101 is secreted from enteroendocrine L\u2009cells mainly expressed in the lower small intestine and colon by the stimulation of various nutrients. The mechanism of GIP secretion induced by nutrients, especially carbohydrates, is different from that of GLP\u20101 secretion. GIP promotes fat deposition in adipose tissue, and contributes to fat\u2010induced obesity. In contrast, GLP\u20101 participates in reducing bodyweight by suppressing food consumption and\/or slowing gastric emptying. There is substantial evidence that GIP and GLP\u20101 might differently contribute to bodyweight control. Although meal contents influence both glycemic and weight control, we do not fully understand whether incretin actions differ depending on the contents of the meal and what kind of signaling is involved in its context. We focus on the molecular mechanism of GIP secretion induced by nutrients, as well as the roles of GIP in weight changes caused by various diets.<\/jats:p>","DOI":"10.1111\/jdi.13816","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T13:05:56Z","timestamp":1650632756000},"page":"1122-1128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Roles of <scp>glucose\u2010dependent<\/scp> insulinotropic polypeptide in <scp>diet\u2010induced<\/scp> obesity"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9099-3493","authenticated-orcid":false,"given":"Yusuke","family":"Seino","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism Fujita Health University  Toyoake 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