{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:25:26Z","timestamp":1747185926026,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004721","name":"University of Tokyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004721","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Leptin replacement therapy (LRT) has drastically improved the prognosis of patients with lipodystrophy, but pro\u2010inflammatory properties of leptin could become evident in the long term. Here, we report a 30\u2010year\u2010old Japanese woman with generalized lipodystrophy\u2010associated progeroid syndrome due to a heterozygous <jats:italic>LMNA<\/jats:italic> variant (c.29C\u2009&gt;\u2009T; p.T10I), who was diagnosed with severe aortic stenosis (AS) after more than a decade of LRT, which required transcatheter aortic valve implantation. Given her marked hypoadiponectinemia and the <jats:italic>LMNA<\/jats:italic> variant, our patient might have been susceptible to progeria\u2010associated disorders, including aortic stenosis, which could have been exaggerated by the prolonged \u2018imbalanced adipokines\u2019 caused by LRT between pro\u2010inflammatory leptin and anti\u2010inflammatory adiponectin. Thus, long\u2010term LRT could be associated with AS in patients with the <jats:italic>LMNA<\/jats:italic> variant to cause generalized lipodystrophy\u2010associated progeroid syndrome and hypoadiponectinemia.<\/jats:p>","DOI":"10.1111\/jdi.13827","type":"journal-article","created":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T07:24:18Z","timestamp":1651908258000},"page":"1636-1638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Severe aortic stenosis during leptin replacement therapy in a patient with generalized lipodystrophy\u2010associated progeroid syndrome due to an <i>LMNA<\/i> variant: A case report"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7644-309X","authenticated-orcid":false,"given":"Takayoshi","family":"Sasako","sequence":"first","affiliation":[{"name":"Department of Diabetes and Metabolic Diseases Graduate School of Medicine The University of Tokyo  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Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kadowaki","sequence":"additional","affiliation":[{"name":"Toranomon Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimasa","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Metabolic Diseases Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012437"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1546"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/534320"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108461"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.018"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(02)00385-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327588"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.485540"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-02078"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/90984"}],"container-title":["Journal 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