{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:25:31Z","timestamp":1747185931446,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Insulin sensitivity and \u03b2\u2010cell function are affected by lipid metabolism disorders, even before the onset of type\u20092 diabetes. People are in the postprandial state most of the time. Therefore, identifying postprandial hyperlipemia is important. This study aimed to assess patients with abnormalities in lipid metabolism, but with normal glucose tolerance, using oral fat tolerance testing (OFTT) to identify defects in insulin sensitivity and \u03b2\u2010cell function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We included 248 volunteers with normal glucose tolerance who underwent OFTT. They were divided into three groups in accordance with their fasting and 4\u2010h postprandial triglyceride (TG) concentrations. Their lipid concentrations during OFTT were compared. The disposition index (DI) was applied to estimate \u03b2\u2010cell function, and the Matsuda insulin sensitivity index (ISI<jats:sub>M<\/jats:sub>) was used to assess insulin sensitivity. We used multiple linear regression analysis to estimate the relationships of fasting and postprandial TG concentrations with \u03b2\u2010cell function and insulin sensitivity .<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The changes in TG concentrations during OFTT were more marked than those in low\u2010density lipoprotein\u2010cholesterol, high\u2010density lipoprotein\u2010cholesterol or total cholesterol concentrations. As lipid metabolism deteriorated, the ISI<jats:sub>M<\/jats:sub> and the DI gradually decreased. Multiple linear regression analysis showed that fasting and 4\u2010h postprandial TG concentrations affected LnISI<jats:sub>M<\/jats:sub> and LnDI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In individuals with normal glucose tolerance, \u03b2\u2010cell function and insulin sensitivity gradually decrease with a deterioration in the lipid profile. Not only fasting TG, but also postprandial TG concentrations are independent risk factors for impaired \u03b2\u2010cell function and insulin resistance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13867","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T12:19:22Z","timestamp":1654777162000},"page":"1805-1813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Oral fat tolerance testing identifies abnormal pancreatic <scp>\u03b2\u2010cell<\/scp> function and insulin resistance in individuals with normal glucose tolerance"],"prefix":"10.1111","volume":"13","author":[{"given":"Lifang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hebei Medical University  Shijiazhuang Hebei China"},{"name":"Department of Endocrinology Hebei General Hospital  Shijiazhuang Hebei China"},{"name":"Department of Endocrinology Baoding First Central Hospital  Baoding 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