{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:31:27Z","timestamp":1773304287661,"version":"3.50.1"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>The aim of this study was to examine the correlation between serum vitamin\u2009D concentrations and prognosis among Chinese individuals with diabetic foot ulcers (DFUs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We retrospectively recruited 488 adults with DFUs in West China Hospital from 1 January 2012 to 31 December 2019. After telephone follow up, 275 patients were finally included. We compared serum vitamin\u2009D concentrations among DFUs patients with different prognostic status, and examined the association of vitamin\u2009D status with prognostic variables by Kaplan\u2013Meier analysis. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals for all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median concentration of serum vitamin\u2009D of patients with DFUs was 37.78\u2009nmol\/L (interquartile range 27.91\u201350.66\u2009nmol\/L), with 31.6% having vitamin\u2009D deficiency (&lt;30\u2009nmol\/L) and 42.2% having insufficient vitamin\u2009D (&lt;50\u2009nmol\/L). During a median follow\u2010up period of 52\u2009months, 65 patients died, with an all\u2010cause mortality of 23.64%. Vitamin\u2009D deficiency was independently linked to increased all\u2010cause mortality after multivariable adjustments (hazard ratio 0.565, 95% confidence interval 0.338\u20130.946,<jats:italic>P<\/jats:italic>\u2009=\u20090.030). There were no significant differences between vitamin\u2009D concentrations and other outcomes of DFUs. Patients who suffered amputations had a tendency of lower vitamin\u2009D concentrations (34.00 [interquartile range 26.90\u201341.81] vs 40.21 [interquartile range 29.60\u201353.96]\u2009nmol\/L,<jats:italic>P<\/jats:italic>\u2009=\u20090.053).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vitamin\u2009D deficiency was significantly associated with increased all\u2010cause mortality in Chinese individuals with DFUs. Vitamin\u2009D supplementation might be a potential therapy for DFUs to prevent premature death and improve outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13917","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T13:48:25Z","timestamp":1665064105000},"page":"122-131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association of vitamin\u2009D status with<scp>all\u2010cause<\/scp>mortality and outcomes among Chinese individuals with diabetic foot ulcers"],"prefix":"10.1111","volume":"14","author":[{"given":"Weiwei","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Innovation Center for Wound Repair, Diabetic Foot Care Center, West China Hospital Sichuan University Chengdu 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