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Here, we report a case of a 31\u2010year\u2010old man who presented with recurrent hypoglycemic events that resolved on discontinuation of methadone. Thus, if hypoglycemia occurs while a patient takes methadone, the amount should be reduced or replaced with another opioid before a full investigation for inappropriate hyperinsulinism is initiated.<\/jats:p>","DOI":"10.1111\/jdi.13919","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T15:10:40Z","timestamp":1665069040000},"page":"145-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Methadone\u2010induced hypoglycemia: A case report"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9297-4889","authenticated-orcid":false,"given":"Ramin","family":"Malboosbaf","sequence":"first","affiliation":[{"name":"Endocrine Research Center, Institute of Endocrinology and Metabolism Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Hatami","sequence":"additional","affiliation":[{"name":"Endocrine Research Center, Institute of Endocrinology and Metabolism Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohreh","family":"Maghsoomi","sequence":"additional","affiliation":[{"name":"Endocrine Research Center, Institute of Endocrinology and Metabolism Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,6]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"1","article-title":"Methadone induced hypoglycemia, improved on dose adjustment","volume":"18","author":"Otalora Y","year":"2020","journal-title":"J Clin Transl Endocrinol Case Rep"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-013-9919-6"},{"key":"e_1_2_5_4_1","first-page":"688","article-title":"Studies on the mechanism of hypoglycemia induced by intrathecal morphine: dissociation from behavioral effects, effects of tolerance, and depletion of liver glycogen","volume":"249","author":"Lux F","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(89)90547-X"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1018648"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2017.1338347"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2015.08.003"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12562"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.5055\/jom.2013.0144"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48955-y"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.13919","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdi.13919","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.13919","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T10:11:55Z","timestamp":1692267115000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.13919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,6]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/jdi.13919"],"URL":"https:\/\/doi.org\/10.1111\/jdi.13919","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,6]]},"assertion":[{"value":"2022-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}