{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:35:11Z","timestamp":1771475711582,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007664","name":"Manpei Suzuki Diabetes Foundation","doi-asserted-by":"publisher","award":["Research grant"],"award-info":[{"award-number":["Research grant"]}],"id":[{"id":"10.13039\/501100007664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["Grants\u2010in\u2010Aid for Scientific Research, 17K09852"],"award-info":[{"award-number":["Grants\u2010in\u2010Aid for Scientific Research, 17K09852"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["Grants\u2010in\u2010Aid for Scientific Research, 21K08589"],"award-info":[{"award-number":["Grants\u2010in\u2010Aid for Scientific Research, 21K08589"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>In the development of type\u20091 diabetes, metabolites are significantly altered and might be involved in \u03b2\u2010cell destruction and protection. We aimed to identify new metabolic markers of \u03b2\u2010cell destruction in type\u20091 diabetes patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 33 participants were recruited for this cross\u2010sectional observational study: 23 with type\u20091 diabetes, seven with type\u20092 diabetes and three healthy controls. Those with type\u20091 diabetes were further subdivided into three groups: new\u2010onset, microsecretors and complete lack of endogenous insulin in type\u20091 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Metabolomic analysis identified a total of 737 peaks, and partial least square analysis was successful in discriminating between the three groups of type\u20091 diabetes. Among the factor loadings discriminating type\u20091 diabetes, 3\u2010phenylpropionic acid (<jats:italic>r<\/jats:italic>\u2009=\u20090.80, <jats:italic>P<\/jats:italic>\u2009=\u20094.7E<jats:sup>\u22126<\/jats:sup>) and hypotaurine (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.484, <jats:italic>P<\/jats:italic>\u2009=\u20091.9E<jats:sup>\u22122<\/jats:sup>) strongly contributed to identifying new\u2010onset type\u20091 diabetes, and 5\u2010methylcytosine to identifying complete\u2010lack type\u20091 diabetes (<jats:italic>r<\/jats:italic>\u2009=\u20090.586, <jats:italic>P<\/jats:italic>\u2009=\u20096.5E<jats:sup>\u22123<\/jats:sup>). Reporter operating characteristics analysis, including all type\u20091 diabetes, type\u20092 diabetes and healthy controls, showed that high 3\u2010phenylpropionic acid (<jats:italic>Pc<\/jats:italic>\u2009&lt;0.0001) and low hypotaurine (<jats:italic>Pc<\/jats:italic>\u2009&lt;0.0001) were useful for identifying new\u2010onset type\u20091 diabetes, and high 5\u2010methylcytosine (<jats:italic>Pc<\/jats:italic>\u2009=\u20090.002) for the complete\u2010lack type\u20091 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the present study, metabolic signatures were shown to be useful in identifying type\u20091 diabetes at different clinical stages, and 3\u2010phenylpropionic acid and hypotaurine are novel biomarkers for identifying new\u2010onset type\u20091 diabetes, suggesting the involvement of the gut bacterial environment, anti\u2010oxidant mechanisms through the hypotaurine\u2010taurine pathway and methylated deoxyribonucleic acid fragmentation in the process of \u03b2\u2010cell destruction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13926","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T13:16:07Z","timestamp":1665666967000},"page":"48-57","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Metabolic signatures of \u03b2\u2010cell destruction in type\u20091 diabetes"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0943-8450","authenticated-orcid":false,"given":"Shinsuke","family":"Noso","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Metabolism and Diabetes Kindai University Faculty of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2466-1228","authenticated-orcid":false,"given":"Naru","family":"Babaya","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism 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