{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:56:24Z","timestamp":1787237784151,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["21AA2007"],"award-info":[{"award-number":["21AA2007"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Introduction<\/jats:title>\n                    <jats:p>Little is known about the relationship between cardiovascular health (CVH) metrics and the risk of developing prediabetes or diabetes. We examined the association of CVH metrics with the annual risk of developing prediabetes or diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      We carried out this study including 403,857 participants aged 18\u201371\u2009years with available data on fasting plasma glucose (FPG) data for five consecutive years and with normal FPG (&lt;100\u2009mg\/dL) at the initial health checkup. We identified the following ideal CVH metrics: non\u2010smoking, body mass index of &lt;25\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , maintaining physical activity, taking breakfast, untreated blood pressure of &lt;120\/80\u2009mmHg and untreated total cholesterol of &lt;200\u2009mg\/dL. We defined the primary end\u2010point as prediabetes (FPG 100\u2013125\u2009mg\/dL) or diabetes (FPG \u2265126\u2009mg\/dL or use of antihyperglycemic medications). We examined the relationship of CVH metrics with the annual incidence of prediabetes or diabetes. Additionally, we examined the association of 1\u2010year changes in CVH metrics with the risk for prediabetes or diabetes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median age was 44\u2009years, and 65.6% were men. An increasing number of non\u2010ideal CVH metrics was associated with an elevated risk of prediabetes or diabetes. A non\u2010ideal body mass index was most strongly associated with the risk of prediabetes or diabetes. The risk of developing prediabetes or diabetes rose as the number of non\u2010ideal CVH metrics increased over 1\u2009year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CVH metrics could stratify the risk of the annual development of prediabetes or diabetes. The risk of developing prediabetes or diabetes might be reduced by improving CVH metrics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.13958","type":"journal-article","created":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T03:15:33Z","timestamp":1670642133000},"page":"452-462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of cardiovascular health metrics with annual incidence of prediabetes or diabetes: Analysis of a nationwide real\u2010world database"],"prefix":"10.1111","volume":"14","author":[{"given":"Akira","family":"Okada","sequence":"first","affiliation":[{"name":"Department of Prevention of Diabetes and Lifestyle\u2010Related Diseases, Graduate School of Medicine The University of Tokyo  Tokyo 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