{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:25:47Z","timestamp":1747185947227,"version":"3.40.5"},"reference-count":69,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012155","name":"National Institute for Medical Research Development","doi-asserted-by":"publisher","award":["958386"],"award-info":[{"award-number":["958386"]}],"id":[{"id":"10.13039\/501100012155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>We aimed to determine the incidence trend of childhood type\u20091 diabetes mellitus in Isfahan province over a period of 12\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this retrospective study, children aged &lt;20\u2009years at the time of type\u20091 diabetes mellitus diagnosis, from March 2007 to March 2019, were included. The crude and adjusted incidence rate of type\u20091 diabetes mellitus is calculated as the number of cases per 100,000\u2009person\u2010years by the period. The cumulative, age\u2010 and sex\u2010specific incidence rates were also calculated. Age\u2010specific incidence rates were calculated for age and sex groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1,954 (983 boys and 971 girls) cases of type\u20091 diabetes mellitus were identified. The mean age at diagnosis in all studied populations was 9.89 (standard deviation 4.76). There were no significant differences between the proportion of boys and girls in different years (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.12) and different age groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.19). The average annual percent change of incidence rate for the total population, for girls and boys, was 6.9%, 6.7% and 6.3% respectively. The type\u20091 diabetes mellitus incidence rate had a significant trend to be increased from 2007 to 2019 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001,<jats:italic>t<\/jats:italic>\u00a0=\u00a03.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings showed that currently our region is considered a region with a high incidence rate of type\u20091 diabetes mellitus. Although we have had fluctuations in the incidence rate over the 12\u2009years, the overall trend is increasing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13975","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T08:00:35Z","timestamp":1674633635000},"page":"376-386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Trends in incidence rates of childhood type\u20091 diabetes mellitus: A retrospective study in Isfahan province, Iran"],"prefix":"10.1111","volume":"14","author":[{"given":"Mahin","family":"Hashemipour","sequence":"first","affiliation":[{"name":"Metabolic Liver Diseases Research Center, Isfahan Endocrine and Metabolism Research Center Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammadreza","family":"Maracy","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Health Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaghayegh Haghjooy","family":"Javanmard","sequence":"additional","affiliation":[{"name":"Applied Physiology Research Center Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzane","family":"Zamaneh","sequence":"additional","affiliation":[{"name":"Metabolic Liver Diseases Research Center Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neda","family":"Mostofizadeh","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Isfahan Endocrine and Metabolism Research Center, Imam Hossein Children's Hospital Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8548-781X","authenticated-orcid":false,"given":"Silva","family":"Hovsepian","sequence":"additional","affiliation":[{"name":"Metabolic Liver Diseases Research Center, Imam Hossein Children's Hospital Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-00443-4"},{"key":"e_1_2_6_3_1","unstructured":"LucierJ WeinstockRS.Diabetes mellitus type 1. 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