{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T17:31:00Z","timestamp":1765560660941,"version":"3.48.0"},"reference-count":0,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Type 2 diabetes mellitus (T2DM) is a common public health problem in the world. Patients with T2DM patients are accompanied with the risk of cardiovascular disease. Clarification of the potential molecular mechanism underlying vascular complications in diabetes mellitus (DM) is crucial for avoiding cardiovascular disease. Fibroblast growth factor 11 (FGF11) is a member of FGF family which, as reported before, can play a causative role in vascular dysfunction in T2DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials &amp; Methods<\/jats:title>\n                    <jats:p>Human microvascular endothelial cells (HMVECs) were treated with high glucose (HG) to simulate T2DM model. Functional assays were carried out to disclose the cell proliferation, apoptosis, migration and angiogenesis of HG\u2010treated HMVECs. Several mechanical experiments including RNA pull down, luciferase reporter and RNA immunoprecipitation (RIP) determined the regulatory mechanism of FGF11 in HG\u2010treated HMVECs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>FGF11 displayed a low expression in HG\u2010treated HMVECs. FGF11 overexpression inhibited proliferation, migration and angiogenesis of HMVECs while facilitated the cell apoptosis in under HG condition. Moreover, FGF11 was targeted by miR\u2010520a\u20105p and miR\u2010432\u20105p, and CTBP1\u2010AS2 acted as a competing endogenous RNA to modulate FGF11 expression via sponging miR\u2010520a\u20105p and miR\u2010432\u20105p.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The axis of CTBP1\u2010AS2\/miR\u2010520a\u20105p\/miR\u2010432\u20105p\/FGF11 might be a potential target for T2DM treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.13990","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T17:28:17Z","timestamp":1765560497000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>FGF11<\/scp>\n                    regulated by\n                    <scp>CTBP1\u2010AS2<\/scp>\n                    \/\n                    <scp>miR<\/scp>\n                    \u2010520a\u20105p\/\n                    <scp>miR<\/scp>\n                    \u2010432\u20105p axis inhibits the progression and angiogenesis in high glucose\u2010treated human microvascular endothelial cells"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6864-7888","authenticated-orcid":false,"given":"Tianhua","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery the Second Affiliated Hospital of Harbin Medical University 150086  Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery the Second Affiliated Hospital of Harbin Medical University 150086  Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery the Second Affiliated Hospital of Harbin Medical University 150086  Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongjie","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery the Second Affiliated Hospital of Harbin Medical University 150086  Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,12]]},"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.13990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T17:28:18Z","timestamp":1765560498000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.13990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,12]]},"references-count":0,"alternative-id":["10.1111\/jdi.13990"],"URL":"https:\/\/doi.org\/10.1111\/jdi.13990","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"type":"print","value":"2040-1116"},{"type":"electronic","value":"2040-1124"}],"subject":[],"published":{"date-parts":[[2025,12,12]]},"assertion":[{"value":"2022-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jdi.13990"}}