{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T02:45:07Z","timestamp":1748745907762,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Pancreatic islet transplantation is a \u03b2\u2010cell replacement therapy for people with insulin\u2010deficient diabetes who have difficulty in glycemic control and suffer from frequent severe hypoglycemia. However, the number of islet transplantations carried out is still limited in Asia. We report a case of allogeneic islet transplantation in a 45\u2010year\u2010old Japanese man with type\u20091 diabetes. Although the islet transplantation was successfully carried out, graft loss was observed on the 18th day. Immunosuppressants were used in accordance with the protocol, and donor\u2010specific anti\u2010human leukocyte antigen antibodies were not detected. Autoimmunity relapse was also not observed. However, the patient had a high titer of anti\u2010glutamic acid decarboxylase antibody from before the islet transplantation, and autoimmunity might thus have affected the \u03b2\u2010cells in the transplanted islet. The evidence is still scarce to reach conclusions, and further data accumulation is required to enable proper patient selection before islet transplantation.<\/jats:p>","DOI":"10.1111\/jdi.13996","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T06:40:09Z","timestamp":1677739209000},"page":"725-729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Graft failure after allogeneic islet transplantation in a patient with type\u20091 diabetes and a high <scp>anti\u2010<\/scp>glutamic acid decarboxylase antibody titer"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4443-1545","authenticated-orcid":false,"given":"Noriko","family":"Kodani","sequence":"first","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Chujo","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine  Tokyo Japan"},{"name":"Center for Clinical Research Toyama University Hospital  Toyama Japan"},{"name":"Department of Pancreatic Islet cell Transplantation National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiko","family":"Terakawa","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoji","family":"Ito","sequence":"additional","affiliation":[{"name":"Hepato\u2010Biliary\u2010Pancreatic Surgery Division, Department of Surgery National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuyuki","family":"Inagaki","sequence":"additional","affiliation":[{"name":"Hepato\u2010Biliary\u2010Pancreatic Surgery Division, Department of Surgery National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Takemura","sequence":"additional","affiliation":[{"name":"Hepato\u2010Biliary\u2010Pancreatic Surgery Division, Department of Surgery National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Pancreatic Islet cell Transplantation National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Tajima","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Ohmagari","sequence":"additional","affiliation":[{"name":"Disease Control and Prevention Center National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumiko","family":"Ajima","sequence":"additional","affiliation":[{"name":"Department of Pancreatic Islet cell Transplantation National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Takaki","sequence":"additional","affiliation":[{"name":"Department of Pancreatic Islet cell Transplantation National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yzumi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Pancreatic Islet cell Transplantation 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