{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:14:08Z","timestamp":1758125648682,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>This study aimed to compare the positivity rates of glutamic acid decarboxylase autoantibodies (GADA) and ElisaRSR\u2122 3 Screen ICA\u2122 (3 Screen ICA), a newly developed assay for the simultaneous measurement of GADA, insulinoma\u2010associated antigen\u20102 autoantibodies (IA\u20102A), and zinc transporter 8 autoantibodies (ZnT8A), in recently obtained sera from patients who had been previously diagnosed with slowly progressive type 1 diabetes (SPIDDM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We enrolled 53 patients with SPIDDM who were positive for GADA at the diagnosis and 98 non\u2010diabetic individuals, and investigated the diagnostic accuracy of the 3 Screen ICA (cutoff index \u226530 units) compared with that of GADA. In addition, we compared the clinical characteristics of patients with SPIDDM who were negative or positive on 3 Screen ICA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The positivity rates of 3 Screen ICA, GADA, IA\u20102A, and ZnT8A were 88.7, 86.8, 24.5, and 13.2%, respectively. The respective sensitivity, specificity, and positive and negative predictive values for SPIDDM were 88.7, 100, 100, and 94.2% by 3 Screen ICA and 86.8, 100, 100.0, and 93.3% by GADA. There were no significant differences in age at onset, duration of diabetes, body mass index, glycated hemoglobin and C\u2010peptide levels, and the prevalence of autoimmune thyroiditis between patients with SPIDDM who were positive or negative on 3 Screen ICA. However, the prevalence of insulin users was significantly higher in those who were positive than in those who were negative on 3 Screen ICA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Similar to GADA, 3 Screen ICA may be a useful diagnostic tool for detecting patients with SPIDDM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.14016","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T06:40:20Z","timestamp":1682059220000},"page":"856-863","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of positive rates between glutamic acid decarboxylase antibodies and <scp>ElisaRSR<\/scp>\u2122 3 Screen <scp>ICA<\/scp>\u2122 in recently obtained sera from patients who had been previously diagnosed with slowly progressive type 1 diabetes"],"prefix":"10.1111","volume":"14","author":[{"given":"Nobuaki","family":"Takehana","sequence":"first","affiliation":[{"name":"Division of Diabetes, Metabolism and Endocrinology, Department of Medicine Showa University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8535-008X","authenticated-orcid":false,"given":"Tomoyasu","family":"Fukui","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Metabolism and Endocrinology, Department of Medicine Showa University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusaku","family":"Mori","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Metabolism and Endocrinology, Department of Medicine Showa University School of Medicine  Tokyo Japan"},{"name":"Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Anti\u2010glycation Research Section Showa University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munenori","family":"Hiromura","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Metabolism and Endocrinology, Department of Medicine Showa University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7405-7419","authenticated-orcid":false,"given":"Michishige","family":"Terasaki","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Metabolism and Endocrinology, Department of Medicine Showa University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Ohara","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Metabolism and Endocrinology, Department of Medicine Showa University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiya","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Showa University Northern Yokohama Hospital  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Tomoyasu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Showa University Northern Yokohama Hospital  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Ito","sequence":"additional","affiliation":[{"name":"Eiju General Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4364-2527","authenticated-orcid":false,"given":"Tetsuro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Division of Immunology and Molecular Medicine Okinaka Memorial Institute for Medical Research  Tokyo 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characteristics of slowly progressive insulin\u2010dependent (type 1) diabetes mellitus (SPIDDM): 1st subcommittee report on SPIDDM, committee on type 1 diabetes, Japan Diabetes Society","volume":"54","author":"Tanaka S","year":"2011","journal-title":"J Jpn Diabetes Soc"},{"doi-asserted-by":"publisher","key":"e_1_2_7_14_1","DOI":"10.2147\/DMSO.S191007"},{"doi-asserted-by":"publisher","key":"e_1_2_7_15_1","DOI":"10.2337\/diacare.25.6.995"},{"doi-asserted-by":"publisher","key":"e_1_2_7_16_1","DOI":"10.1111\/jdi.13910"}],"container-title":["Journal of Diabetes 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