{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:25:55Z","timestamp":1747185955452,"version":"3.40.5"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>A deficit of \u03b2\u2010cells is a salient feature in both type\u20091 and type\u20092 diabetes mellitus. Due to the absolute lack of supplying \u03b2\u2010cells for organ or cell transplantation, there is an urgent need to explore the efficient method to generate insulin\u2010producing cells. Cell conversion of intestinal cryptic epithelial cells to insulin\u2010producing \u03b2\u2010like cells is a novel and promising therapeutic target. Activation of \u03b2\u2010cell differentiation factors or modulation of terminally differentiated factors with forkhead homeobox O1 effectively induced such conversion, and suppressed hyperglycemia in streptozotocin\u2010induced and non\u2010obese diabetic (NOD) mice. Segi's cap, which was discovered &gt;80\u2009years ago, is composed of an aggregation of primitive granulated enteroendocrine cells, enterochromaffin cells, Paneth cells and goblet cells in the intestinal villi, and is only detected at the fetal stage. Its role has long been unknown, but the present study disclosed that it likely provides an underpin of newly generated \u03b2\u2010like cells.<\/jats:p>","DOI":"10.1111\/jdi.14025","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T06:16:05Z","timestamp":1683094565000},"page":"838-840","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut as a source of new \u03b2\u2010cells and Segi's cap"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4255-774X","authenticated-orcid":false,"given":"Soroku","family":"Yagihashi","sequence":"first","affiliation":[{"name":"Department of Explorative Medicine on Nature, Life and Humans Toho University School of Medicine  Chiba Japan"},{"name":"Department of Pathology Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI162720"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-0375-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.02.013"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01586-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc1950.43.79"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.14025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T16:13:04Z","timestamp":1692461584000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.14025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,2]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/jdi.14025"],"URL":"https:\/\/doi.org\/10.1111\/jdi.14025","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"type":"print","value":"2040-1116"},{"type":"electronic","value":"2040-1124"}],"subject":[],"published":{"date-parts":[[2023,5,2]]},"assertion":[{"value":"2023-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}