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Despite recent significant improvements of life expectancy in patients with diabetes, there is still a need for efforts to elucidate the complexities and mechanisms of the disease processes to overcome this difficult disorder. To this end, the use of appropriate animal models in diabetes studies is invaluable for translation to humans and for the development of effective treatment. In this review, a variety of animal models of diabetes with spontaneous onset in particular will be introduced and discussed for their implication in diabetes research.<\/jats:p>","DOI":"10.1111\/jdi.14034","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:45:40Z","timestamp":1688431540000},"page":"1015-1037","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Contribution of animal models to diabetes research: Its history, significance, and translation to humans"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4255-774X","authenticated-orcid":false,"given":"Soroku","family":"Yagihashi","sequence":"first","affiliation":[{"name":"Department of Exploratory Medicine for Nature, Life and Humans Toho University School of Medicine  Chiba Japan"},{"name":"Department of Pathology Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2005.01499.x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01911.x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.2183\/pjab1945.51.80"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.119.85"},{"key":"e_1_2_13_6_1","first-page":"140","article-title":"Animal models of obesity and diabetes mellitus","volume":"14","author":"Kleinert M","year":"2018","journal-title":"Nat Rev"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530319666190626143832"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05415-0"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.08.006"},{"key":"e_1_2_13_10_1","first-page":"379","article-title":"Diagnostic criteria of diabetes in experimental animal models","volume":"53","author":"Report of the Japan Society of Experimental Diabetes and Obesity Working Group (in Japanese)","year":"2010","journal-title":"J Jpn Soc Diabetes"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.26.2.100"},{"key":"e_1_2_13_12_1","first-page":"1","volume-title":"Animal Models of Diabetes. 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