{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T07:43:13Z","timestamp":1782200593312,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007664","name":"Manpei Suzuki Diabetes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007434","name":"Suzuken Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>It is crucial to develop practical and noninvasive methods to assess the functional beta\u2010cell mass in a donor pancreas, in which monitoring and precise evaluation is challenging. A patient with type 1 diabetes underwent noninvasive imaging following simultaneous kidney\u2013pancreas transplantation with positron emission tomography\/computed tomography (PET\/CT) using an exendin\u2010based probe, [<jats:sup>18<\/jats:sup>F]FB(ePEG12)12\u2010exendin\u20104. Following transplantation, PET imaging with [<jats:sup>18<\/jats:sup>F]FB(ePEG12)12\u2010exendin\u20104 revealed simultaneous and distinct accumulations in the donor and native pancreases. The pancreases were outlined at a reasonable distance from the surrounding organs using [<jats:sup>18<\/jats:sup>F]FB(ePEG12)12\u2010exendin\u20104 whole\u2010body maximum intensity projection and axial PET images. At 1 and 2\u2009h after [<jats:sup>18<\/jats:sup>F]FB(ePEG12)12\u2010exendin\u20104 administration, the mean standardized uptake values were 2.96 and 3.08, respectively, in the donor pancreas and 1.97 and 2.25, respectively, in the native pancreas. [<jats:sup>18<\/jats:sup>F]FB(ePEG12)12\u2010exendin\u20104 positron emission tomography imaging allowed repeatable and quantitative assessment of beta\u2010cell mass following simultaneous kidney\u2013pancreas transplantation.<\/jats:p>","DOI":"10.1111\/jdi.14045","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T08:59:22Z","timestamp":1687942762000},"page":"1187-1191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Noninvasive evaluation of donor and native pancreases following simultaneous pancreas\u2013kidney transplantation using positron emission tomography\/computed tomography"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3844-1138","authenticated-orcid":false,"given":"Takaaki","family":"Murakami","sequence":"first","affiliation":[{"name":"Department of Diabetes, Endocrinology, and Nutrition, Graduate School of Medicine Kyoto 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