{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T12:38:03Z","timestamp":1783600683821,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T00:00:00Z","timestamp":1688860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Dapagliflozin is used for individuals with type\u20091 diabetes, although the effect of this medication on skeletal muscle mass is not well established. In addition, there are few studies examining the effects of good glycemic control on skeletal muscle mass in type\u20091 diabetes patients. We investigated changes in glycemic control and skeletal muscle mass with dapagliflozin in individuals with type\u20091 diabetes, and the association between these changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This was a post\u2010hoc analysis of a multicenter, open\u2010label, non\u2010randomized, prospective, interventional study in individuals with type\u20091 diabetes. The participants received dapagliflozin at 5\u2009mg\/day for 4\u2009weeks, and were reviewed before and after treatment. Weight\u2010 and height\u2010corrected appendicular skeletal muscle mass (ASM) were calculated as indices of skeletal muscle mass using bioelectrical impedance analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 36 individuals were included in the analysis. After the 4\u2009weeks of dapagliflozin treatment, ASM\/height<jats:sup>2<\/jats:sup> decreased in the body mass index\u2009&lt;23 group (<jats:italic>P<\/jats:italic>\u2009=\u20090.004). ASM\u2009\/\u2009weight decreased in all men aged &gt;60\u2009years. The change in ASM\u2009\/\u2009weight (%) was negatively correlated with the change in glycated hemoglobin (%;<jats:italic>P<\/jats:italic>\u2009=\u20090.023). The change in ASM\u2009\/\u2009height<jats:sup>2<\/jats:sup> (kg\/m<jats:sup>2<\/jats:sup>) was also positively correlated with the change in time within the glucose range of 70\u2013180\u2009mg\/dL (<jats:italic>P<\/jats:italic>\u2009=\u20090.036).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dapagliflozin treatment of individuals with type\u20091 diabetes, particularly non\u2010obese individuals and older men, might result in loss of skeletal muscle mass. However, good glycemic control during treatment might prevent the onset and progression of sarcopenia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.14054","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T06:53:42Z","timestamp":1688972022000},"page":"1175-1182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Changes in glycemic control and skeletal muscle mass indices after dapagliflozin treatment in individuals with type\u20091 diabetes mellitus"],"prefix":"10.1111","volume":"14","author":[{"given":"Yuta","family":"Yoshimura","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Kyoto Prefectural University of Medicine, Graduate School of Medical Science  Kyoto Japan"},{"name":"Department of Metabolism and Immunology Saiseikai Suita Hospital  Suita 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