{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:26:02Z","timestamp":1747185962707,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000361","name":"Diabetes UK","doi-asserted-by":"publisher","award":["16\/0005407"],"award-info":[{"award-number":["16\/0005407"]}],"id":[{"id":"10.13039\/501100000361","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["105636\/Z\/14\/Z"],"award-info":[{"award-number":["105636\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["098395\/Z\/12\/Z","105636\/Z\/14\/Z","110082\/Z\/15\/Z"],"award-info":[{"award-number":["098395\/Z\/12\/Z","105636\/Z\/14\/Z","110082\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The incretin hormones glucagon\u2010like peptide\u20101 (GLP\u20101) and glucose\u2010dependent insulinotropic polypeptide (GIP), are thought to be the main drivers of insulin secretion in individuals with sulfonylurea (SU)\u2010treated <jats:italic>KCNJ11<\/jats:italic> permanent neonatal diabetes. The aim of this study was to assess for the first time the incretin hormone response to carbohydrate and protein\/fat in adults with sulfonylurea\u2010treated <jats:italic>KCNJ11<\/jats:italic> permanent neonatal diabetes compared with that of controls without diabetes. Participants were given a breakfast high in carbohydrate and an isocaloric breakfast high in protein\/fat on two different mornings. Incremental area under the curve and total area under the curve (0\u2010240 minutes)\u00a0for total GLP\u20101 and GIP were compared between groups, using non\u2010parametric statistical methods. Post\u2010meal GLP\u20101 and GIP secretion were similar in cases and controls, suggesting this process is adenosine triphosphate\u2010sensitive potassium channel\u2010independent. Future research will investigate whether treatments targeting the incretin pathway are effective in individuals with <jats:italic>KCNJ11<\/jats:italic> permanent neonatal diabetes who do not have good glycemic control on sulfonylurea alone.<\/jats:p>","DOI":"10.1111\/jdi.14071","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T03:26:46Z","timestamp":1692674806000},"page":"1378-1382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incretin hormone responses to carbohydrate and protein\/fat are preserved in adults with sulfonylurea\u2010treated <i>KCNJ11<\/i> neonatal diabetes"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5241-7700","authenticated-orcid":false,"given":"Pamela","family":"Bowman","sequence":"first","affiliation":[{"name":"University of Exeter Medical School  Exeter UK"},{"name":"Exeter NIHR Clinical Research Facility  Exeter 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