{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:26:03Z","timestamp":1747185963401,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Coronavirus disease 2019 (COVID\u201019) vaccinations have been proven to be generally safe in healthy populations. However, the data on vaccine safety in patients with type\u20091 diabetes are scarce. This study aimed to evaluate the frequency and severity of short\u2010term (&lt;7\u2010day) adverse vaccination events (AEs) and their risk factors among type\u20091 diabetes patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This study analyzed data from the COVID\u201019 vaccination in Autoimmune Diseases (COVAD) survey database (May to December 2021; 110 collaborators, 94 countries), comparing &lt;7\u2010day COVID\u201019 vaccine AE among type\u20091 diabetes patients and healthy controls (HCs). Descriptive statistics; propensity score matching (1:4) using the variables age, sex and ethnicity; and multivariate analyses were carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study analyzed 5,480 completed survey responses. Of all responses, 5,408 were HCs, 72 were type\u20091 diabetes patients (43 females, 48.0% white European ancestry) and Pfizer was the most administered vaccine (39%). A total of 4,052 (73.9%) respondents had received two vaccine doses. Patients with type\u20091 diabetes had a comparable risk of injection site pain, minor and major vaccine AEs, as well as associated hospitalizations to HCs. However, type\u20091 diabetes patients had a higher risk of severe rashes (3% vs 0.4%, OR 8.0, 95% confidence interval 1.7\u201336), <jats:italic>P<\/jats:italic>\u2009=\u20090.007), although reassuringly, these were rare (<jats:italic>n<\/jats:italic>\u2009=\u20092 among type 1 diabetes patients).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>COVID\u201019 vaccination was safe and well tolerated in patients with type\u20091 diabetes with similar AE profiles compared with HCs, although severe rashes were more common in type\u20091 diabetes patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.14079","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T06:59:49Z","timestamp":1694501989000},"page":"131-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Type\u20091 diabetes, <scp>COVID<\/scp>\u201019 vaccines and short\u2010term safety: Subgroup analysis from the global <scp>COVAD<\/scp> study"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8844-851X","authenticated-orcid":false,"given":"Tulika","family":"Chatterjee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Center for Outcomes Research University of Illinois College of Medicine Peoria  Peoria Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2014-3925","authenticated-orcid":false,"given":"Naveen","family":"Ravichandran","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narmadha","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Royal Wolverhampton Hospitals NHS Trust  Wolverhampton 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India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7312-351X","authenticated-orcid":false,"given":"Mrudula","family":"Joshi","sequence":"additional","affiliation":[{"name":"Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals  Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6745-9770","authenticated-orcid":false,"given":"Sreoshy","family":"Saha","sequence":"additional","affiliation":[{"name":"Mymensingh Medical College  Mymensingh Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3849-614X","authenticated-orcid":false,"given":"Arvind","family":"Nune","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Southport and Ormskirk Hospital NHS Trust  Southport 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