{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:40Z","timestamp":1787015560326,"version":"build-2736575974"},"reference-count":11,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mitochondrial dysfunction causes maternally inherited deafness and diabetes (MIDD). Herein, we report improved glycemic control in a 47\u2010year\u2010old Japanese woman with MIDD using imeglimin without major adverse effects. Biochemical tests and metabolome analysis were performed before and after imeglimin administration. Blood glucose level fluctuations were determined. Sulfonylureas, dipeptidyl peptidase\u20104 inhibitors (DPP4is), and sodium glucose transporter\u20102 inhibitors (SGLT2i) were administered to evaluate the efficacy of their combination with imeglimin. Imeglimin decreased the HbA1c and ammonia levels and increased the time\u2010in\u2010range, C\u2010peptide reactivity, and glucagon level. Elevated citrulline and histamine levels were decreased by imeglimin. The hypoglycemic effect was not enhanced by imeglimin when combined with sulfonylurea or DPP4i, but the blood glucose level was improved when combined with SGLT2i. Imeglimin improved glucose concentration\u2010dependent insulin secretion and maximized the insulin secretory capacity by improving mitochondrial function and glutamine metabolism and urea circuit abnormalities by promoting glucagon secretion. Imeglimin could improve glycemic control in MIDD.<\/jats:p>","DOI":"10.1111\/jdi.14085","type":"journal-article","created":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T01:37:46Z","timestamp":1694828266000},"page":"1419-1422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>Imeglimin\u2010mediated<\/scp>\n                    glycemic control in maternally inherited deafness and diabetes"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2535-5396","authenticated-orcid":false,"given":"Ryoichi","family":"Ishibashi","sequence":"first","affiliation":[{"name":"Division of Diabetes, Endocrinology and Metabolism, Department of Medicine Kimitsu Chuo Hospital  Kisarazu, Chiba Japan"},{"name":"Department of Endocrinology, Hematology, and Gerontology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiichi","family":"Hirayama","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Metabolism, Department of Medicine Kimitsu Chuo Hospital  Kisarazu, Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzuka","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Metabolism, Department of Medicine Kimitsu Chuo Hospital  Kisarazu, Chiba Japan"},{"name":"Department of Endocrinology, Hematology, and Gerontology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Okano","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Metabolism, Department of Medicine Kimitsu Chuo Hospital  Kisarazu, Chiba Japan"},{"name":"Department of Endocrinology, Hematology, and Gerontology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Metabolism, Department of Medicine Kimitsu Chuo Hospital  Kisarazu, Chiba Japan"},{"name":"Department of Endocrinology, Hematology, and Gerontology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Baba","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Metabolism, Department of Medicine Kimitsu Chuo Hospital  Kisarazu, Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuma","family":"Kanayama","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Metabolism, Department of Medicine Kimitsu Chuo Hospital  Kisarazu, Chiba 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Hospital  Kisarazu, Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryohei","family":"Ohtani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Neurology Kimitsu Chuo Hospital  Kisarazu, Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Inaba","sequence":"additional","affiliation":[{"name":"Clinical Research Center Chiba University Hospital  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7374-9993","authenticated-orcid":false,"given":"Masaya","family":"Koshizaka","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hematology, and Gerontology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiro","family":"Maezawa","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hematology, and Gerontology 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