{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:27:45Z","timestamp":1791520065311,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>The aim of this study was to clarify the characteristics of individuals with prediabetes who developed type\u20092 diabetes despite undergoing interventions, and to evaluate the performance of urinary myo\u2010inositol (UMI) as a noninvasive indicator for the risk of developing diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 51 individuals with prediabetes who underwent a 75\u2010g oral glucose tolerance test, \u0394UMI (the difference in the UMI\u2009:\u2009creatinine ratio between before and 120\u2009min after 75\u2010g glucose loading), fasting plasma glucose, insulin, hemoglobin A1c, noninvasive testing (age, body mass index, blood pressure) and general blood tests were measured at baseline, and underwent dietary\/exercise guidance for 8\u2009years were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 31 participants developed diabetes in 8\u2009years. At baseline, the group that developed diabetes was characterized by high \u0394UMI, hemoglobin A1c, fasting plasma glucose and low high\u2010density lipoprotein cholesterol, and insulinogenic index (I.I.). I.I and \u0394UMI showed a higher correlation than fasting plasma glucose and hemoglobin A1c. Regarding diabetes onset within 8\u2009years, Cox regression analysis of diabetes onset showed the baseline \u0394UMI is an independent predictor, adjusted for the result of not only noninvasive markers, but also that of noninvasive and general blood markers. The log\u2010rank test showed that all glycemic indicators were significantly associated with diabetes onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Participants who developed type\u20092 diabetes from prediabetes despite undergoing interventions were characterized by high glycemic control markers and low I.I. As noninvasive measurement of \u0394UMI is associated with I.I. and diabetes onset, it could be a useful indicator for identifying individuals with a high risk of diabetes onset.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.14092","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T04:56:39Z","timestamp":1697086599000},"page":"177-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Characteristics of individuals who developed type\u20092 diabetes from prediabetes despite undergoing interventions, and evaluation of the performance of urinary myo\u2010inositol as a risk factor for developing diabetes"],"prefix":"10.1111","volume":"15","author":[{"given":"Fumio","family":"Yamagata","sequence":"first","affiliation":[{"name":"Genki Plaza Medical Center for Health Care  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Ogata","sequence":"additional","affiliation":[{"name":"Genki Plaza Medical Center for Health Care  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Koda","sequence":"additional","affiliation":[{"name":"Genki Plaza Medical Center for Health Care  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Genki Plaza Medical Center for Health Care  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Suga","sequence":"additional","affiliation":[{"name":"Genki Plaza Medical Center for Health Care  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Kanauchi","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Faculty of Makuhari Human Care Tohto University  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6454-0490","authenticated-orcid":false,"given":"Takuji","family":"Kohzuma","sequence":"additional","affiliation":[{"name":"Asahi Kasei Pharma Corporation  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Kawazu","sequence":"additional","affiliation":[{"name":"Genki Plaza Medical Center for Health Care  Tokyo Japan"},{"name":"Clinic of the Institute of Medical Science Asahi Life Foundation  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"IDF Diabetes Atlas","author":"International Diabetes Federation","year":"2019"},{"issue":"1","key":"e_1_2_6_3_1","first-page":"S1","article-title":"Standards of medical care in diabetes\u20102021","volume":"44","author":"American Diabetes Association","year":"2021","journal-title":"Diabetes Care"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13340-020-00439-5"},{"key":"e_1_2_6_5_1","unstructured":"Japanese Clinical Practice Guideline for Diabetes 2019. 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