{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:19:09Z","timestamp":1790957949684,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In this study, we employed a Mendelian randomization (MR) approach to investigate the independent causal associations of six body composition traits with gestational diabetes mellitus (GDM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Genome\u2010wide significant levels (<jats:italic>P<\/jats:italic>\u2009&lt;\u200910\u2009\u00d7\u20095<jats:sup>\u22128<\/jats:sup>) of single nucleotide polymorphisms associated with body water mass, total protein, whole body fat\u2010free mass, weight, whole body fat mass, and body fat percentage were used as instrumental variables. Data on GDM were obtained from the FinnGen Consortium, and both univariable and multivariable Mendelian randomization were performed. We utilized five different analytical methods including inverse\u2010variance weighted (IVW), MR Egger, weighted median, simple mode, and weighted mode to assess the robustness of the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With univariable Mendelian randomization, the risk of GDM increased per 1\u2010standard deviation (SD) increase in weight (OR<jats:sub>weight<\/jats:sub>\u2009=\u20091.297, <jats:italic>P<\/jats:italic>\u2009=\u20093.06\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup>), whole body fat mass (OR<jats:sub>whole body fat mass<\/jats:sub>\u2009=\u20091.408, <jats:italic>P<\/jats:italic>\u2009=\u20091.32\u2009\u00d7\u200910<jats:sup>\u22126<\/jats:sup>), and the risk of GDM increased per percent increase in body fat percentage (OR<jats:sub>body fat percentage<\/jats:sub>\u2009=\u20091.661, <jats:italic>P<\/jats:italic>\u2009=\u20091.01\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>). Total protein had a protective effect on the risk of GDM (OR<jats:sub>total protein<\/jats:sub>\u2009=\u20090.880, <jats:italic>P<\/jats:italic>\u2009=\u20090.048). However, there was no significant causal association between increases in body water mass and whole body fat\u2010free mass per SD and the risk of GDM. Causal associations between weight, whole body fat mass, body fat percentage, and total protein with GDM were reduced to null in multivariable Mendelian randomization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study furnishes genetic evidence to elucidate the causal relationship between body composition traits and GDM. Additionally, further studies are imperative to establish a causal connection between body composition traits and gestational diabetes mellitus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.14115","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T07:00:52Z","timestamp":1701154852000},"page":"346-354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Body composition and risk of gestational diabetes mellitus: A univariable and multivariable Mendelian randomization study"],"prefix":"10.1111","volume":"15","author":[{"given":"Yuan","family":"Gao","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Nanchang University  Nanchang China"},{"name":"Nursing School of Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1336-2097","authenticated-orcid":false,"given":"Min","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Xu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Yang","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine Jining Medical University  Jining China"},{"name":"Department of General Surgery The First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital)  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man Fen","family":"Qin","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Nanchang University  Nanchang China"},{"name":"Nursing School of Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147649"},{"key":"e_1_2_9_3_1","volume-title":"IDF Diabetes Atlas","author":"Magliano DJ","year":"2021"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2017.02.002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000865"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2021-067946","article-title":"Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta\u2010analysis","volume":"377","author":"Ye 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