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However, while the majority of women with GDM will return to normoglycemia after delivery, they have up to a seven times higher risk of developing type 2 diabetes during midlife, compared with those with no history of GDM. Gestational diabetes mellitus also increases the risk of multiple metabolic disorders, including non\u2010alcoholic fatty liver disease, obesity, and cardiovascular diseases. Lipid metabolism undergoes significant changes throughout the gestational period, and lipid dysregulation is strongly associated with GDM and the progression to future type 2 diabetes. In addition to common lipid variables, discovery\u2010based omics techniques, such as metabolomics and lipidomics, have identified lipid biomarkers that correlate with GDM. These lipid species also show considerable potential in predicting the onset of GDM and subsequent type 2 diabetes post\u2010delivery. This review aims to update the current knowledge of the role that lipids play in the onset of GDM, with a focus on potential lipid biomarkers or metabolic pathways. These biomarkers may be useful in establishing predictive models to accurately predict the future onset of GDM and type 2 diabetes, and early intervention may help to reduce the complications associated with GDM.<\/jats:p>","DOI":"10.1111\/jdi.14119","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T12:33:01Z","timestamp":1702557181000},"page":"15-25","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["The role of lipid dysregulation in gestational diabetes mellitus: Early prediction and postpartum prognosis"],"prefix":"10.1111","volume":"15","author":[{"given":"Ziyi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Sir Run Run Shaw Hospital Zhejiang University, School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zhejiang 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