{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:09:18Z","timestamp":1791216558330,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202040376"],"award-info":[{"award-number":["202040376"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Introduction<\/jats:title>\n                    <jats:p>Simple renal cysts (SRC) are associated with age, hypertension and hyperuricemia, which are risk factors of renal impairment. This study aimed to investigate the prevalence of SRC and its association with measured glomerular filtration rate (mGFR) in patients with type\u20092 diabetes mellitus in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 3,552 patients with type\u20092 diabetes mellitus admitted to Shanghai Sixth People's Hospital from January 2012 to December 2016 were investigated. All participants were diagnosed as SRC by color Doppler, and all participants were measured for GFR by using dynamic renal scintigraphy with technetium\u201099m\u2010diethylene triamine peta\u2010acetic acid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of SRC was 17.4% (619 cases). Participants with SRC had significantly lower mGFR values than those without SRC (86.16\u2009\u00b1\u200926.20 vs 94.88\u2009\u00b1\u200923.98\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). In 478 participants with unilateral renal cyst, the mGFR of the kidney affected by SRC was significantly lower than that of the unaffected kidney (43.32\u2009\u00b1\u200913.74 vs 44.18\u2009\u00b1\u200913.34\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.014). The participants were divided into four groups according to the quartiles of mGFR level (\u2265109.50, 93.80\u2013109.49, 76.90\u201393.79 and &lt;76.90\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      ). The prevalence of SRC gradually increased with decreasing mGFR level (12.9, 13.9, 16.6 and 27.8%, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      trend &lt;0.01). After adjusting for age, sex, duration of diabetes, hypertension and other potential confounders, the logistic regression showed that SRC was an independent risk factor for impaired GFR (&lt;60\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      ; odds ratio 1.656; 95% confidence interval 1.451\u20131.890,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SRC is an independent risk factor for the decrease of mGFR in Chinese diabetes patients, and could affect the renal GFR measured by dynamic renal scintigraphy on the SRC side.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.14120","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T13:08:08Z","timestamp":1702300088000},"page":"26-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Decline in measured glomerular filtration rate is associated with simple renal cyst in Chinese patients with type\u20092 diabetes"],"prefix":"10.1111","volume":"15","author":[{"given":"Fu","family":"Qiaoling","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Haikou Orthopedic and Diabetes Hospital  Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Jingyi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Haikou Orthopedic and Diabetes Hospital  Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Haikou Orthopedic and Diabetes Hospital  Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chaoying","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Haikou Orthopedic and Diabetes Hospital  Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Mingliang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9313-6713","authenticated-orcid":false,"given":"Zhang","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"2569","article-title":"Simple renal cysts: prevalence, associated risk factors and follow\u2010up in a health screening cohort","volume":"13","author":"Ozveren B","year":"2016","journal-title":"Urol 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