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Autophagy of pancreatic \u03b2\u2010cells plays a pivotal role in the maintenance of the mass, structure and function of \u03b2\u2010cells, whose dysregulation can lead to abnormal metabolic profiles or diabetes. Modulators of autophagy are being developed to improve metabolic profile and \u03b2\u2010cell function through the removal of harmful materials and rejuvenation of organelles, such as mitochondria and endoplasmic reticulum. Among the known antidiabetic drugs, glucagon\u2010like peptide\u20101 receptor agonists enhance the autophagic activity of \u03b2\u2010cells, which might contribute to the profound effects of glucagon\u2010like peptide\u20101 receptor agonists on systemic metabolism. In this review, the results from studies on the role of autophagy in \u03b2\u2010cells and their implication in the development of diabetes are discussed. In addition to non\u2010selective (macro)autophagy, the role and mechanisms of selective autophagy and other minor forms of autophagy that might occur in \u03b2\u2010cells are discussed. As \u03b2\u2010cell failure is the ultimate cause of diabetes and unresponsiveness to conventional therapy, modulation of \u03b2\u2010cell autophagy might represent a future antidiabetic treatment approach, particularly in patients who are not well managed with current antidiabetic therapy.<\/jats:p>","DOI":"10.1111\/jdi.14184","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T07:49:47Z","timestamp":1710229787000},"page":"656-668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Role of \u03b2\u2010cell autophagy in \u03b2\u2010cell physiology and the development of diabetes"],"prefix":"10.1111","volume":"15","author":[{"given":"Xaviera Riani","family":"Yasasilka","sequence":"first","affiliation":[{"name":"Soonchunhyang Institute of Medi\u2010bio Science and Division of Endocrinology, Department of Internal Medicine Soonchunhyang University College of Medicine  Cheonan 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