{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:14Z","timestamp":1787015474298,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017550","name":"Shaanxi Science and Technology Association","doi-asserted-by":"publisher","award":["2022JQ\u2010824"],"award-info":[{"award-number":["2022JQ\u2010824"]}],"id":[{"id":"10.13039\/501100017550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016067","name":"Shaanxi Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2019\u2010ZZ\u2010JC050"],"award-info":[{"award-number":["2019\u2010ZZ\u2010JC050"]}],"id":[{"id":"10.13039\/100016067","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019491","name":"National Natural Science Foundation of China - State Grid Corporation Joint Fund for Smart Grid","doi-asserted-by":"publisher","award":["81870172"],"award-info":[{"award-number":["81870172"]}],"id":[{"id":"10.13039\/501100019491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Introduction<\/jats:title>\n                    <jats:p>\n                      Diabetic cardiomyopathy (DCM) is a prevalent condition among individuals with diabetes, and is associated with a high mortality rate. The anti\u2010oxidant properties of Jing Huang or\n                      <jats:italic>Polygonatum sibiricum<\/jats:italic>\n                      polysaccharide (PSP) have been extensively used to treat diabetes\u2010related disorders; however, its potential effectiveness against DCM remains unknown. This study aimed to investigate PSP's therapeutic effects on DCM in an experimental diabetic mouse model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>To induce insulin resistance, mice were fed a high\u2010fat diet for 3\u2009months, followed by intraperitoneal streptozotocin injection to induce slight hyperglycemia and develop DCM. Both DCM and control mice were given PSP orally for 3\u2009weeks. Western blotting was used to detect the protein expressions of protein kinase G, C\/EBP homologous protein, glucose\u2010regulated protein\u200978, phosphodiesterase type\u20095, protein kinase R\u2010like endoplasmic reticulum (ER) kinase, and phospho\u2010protein kinase R\u2010like endoplasmic reticulum kinase in heart tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results showed a reduction in bodyweight and blood glucose levels in the PSP therapy group compared with DCM group. PSP also improved cardiac function and had a negligible effect on malondialdehyde activity. Furthermore, the findings showed that PSP alleviated ER and oxidative stress observed in DCM mice hearts, leading to the inhibition of cyclic guanosine monophosphate\u2010specific phosphodiesterase type\u20095 and cardiac cyclic guanosine monophosphate reactivation. Phosphodiesterase type\u20095 inhibition reduced high\u2010fat diet\u2010induced cardiac dysfunction and decreased ER stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PSP could effectively protect diabetic myocardium by inhibiting endoplasmic reticulum stress. These findings provide crucial insights into the potential of PSP to ameliorate DCM conditions in diabetic mice by decreasing ER and oxidative stress, and enhancing cyclic guanosine monophosphate protein kinase G signaling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.14192","type":"journal-article","created":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T00:40:11Z","timestamp":1711759211000},"page":"823-834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["<i>Polygonatum sibiricum<\/i>\n                    (Huang Jing) polysaccharide reduces diabetic cardiomyopathy through increasing cyclic guanosine monophosphate\u2010protein kinase G signaling in diabetic mice"],"prefix":"10.1111","volume":"15","author":[{"given":"Shengping","family":"Lei","sequence":"first","affiliation":[{"name":"Clinical Experimental Center Xi'an International Medical Center Hospital  Xi'an China"},{"name":"Xi'an 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